Phase I Clinical Trial: Evaluating the Efficacy, Safety, and Patient Satisfaction of Platelet-Rich Plasma Injections and Microneedling for Androgenetic Alopecia Treatment

September 2025 in “ Journal of Cosmetic Dermatology ”

Mohammad Ali Nilforoushzadeh, Masoumeh Roohaninasab, Elham Behrangi, Alireza Jafarzadeh, Maryam Nouri, Solmaz Zare, Sona Zare

platelet-rich plasma microneedling androgenetic alopecia PRP AGA

TLDR PRP and microneedling both effectively improve hair growth and thickness for treating hair loss.

This Phase I clinical trial assessed the efficacy and safety of platelet-rich plasma (PRP) injections and microneedling for androgenetic alopecia (AGA) in 40 patients aged 18-50. Participants were divided into two groups, with one receiving PRP injections and the other undergoing PRP application via microneedling. Both methods improved hair density and thickness, with microneedling showing slightly better results. Patient satisfaction was high, and no severe adverse effects were reported, indicating that PRP treatments, especially when combined with microneedling, are promising options for AGA management. Further large-scale studies are recommended to confirm these findings.

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