Phase I Clinical Trial: Evaluating the Efficacy, Safety, and Patient Satisfaction of Platelet-Rich Plasma Injections and Microneedling for Androgenetic Alopecia Treatment

September 2025 in “ Journal of Cosmetic Dermatology ”

Mohammad Ali Nilforoushzadeh, Masoumeh Roohaninasab, Elham Behrangi, Alireza Jafarzadeh, Maryam Nouri, Solmaz Zare, Sona Zare

platelet-rich plasma microneedling androgenetic alopecia PRP AGA

From the encyclopedia

Platelet-Rich Plasma →

growth factors taken from your blood and injected into your scalp to stimulate hair

Microneedling →

technique to create small wounds in skin to activate collagen production and hair growth

Studysummary This study found that both PRP injections and microneedling treatments significantly improved hair count and thickness in patients with androgenetic alopecia, without significant differences between the two methods. Microneedling also enhanced patient satisfaction and treatment tolerance. Our plain-language summary of this paper — not a Tressless recommendation.

This Phase I clinical trial assessed the efficacy and safety of platelet-rich plasma (PRP) injections and microneedling for androgenetic alopecia (AGA) in 40 patients aged 18-50. Participants were divided into two groups, with one receiving PRP injections and the other undergoing PRP application via microneedling. Both methods improved hair density and thickness, with microneedling showing slightly better results. Patient satisfaction was high, and no severe adverse effects were reported, indicating that PRP treatments, especially when combined with microneedling, are promising options for AGA management. Further large-scale studies are recommended to confirm these findings.

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Research cited in this study

38 / 38 results

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