Topical Finasteride 0.25% in HPCH Spray for Androgenetic Alopecia: A Single-Center Retrospective Study

    July 2026 in “ Archives of Dermatological Research ”
    Abdullah Almeziny, Maha Alkharisi, Shada Khalid Alanazi … Fares A. Alkhayal
    Studysummary In this study, topical finasteride showed mild-to-moderate improvement in androgenetic alopecia among a cohort in Saudi Arabia, with combination therapy outperforming monotherapy. Adverse events were rare. The study highlights the need for prospective trials to clarify finasteride's standalone effects.
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    Research cited in this study 19

    1. Efficacy and Safety of Topical Finasteride Spray Solution in the Treatment of Chinese Men with Androgenetic Alopecia: A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Chinese Medical Journal · 2025
    2. Platelet Rich Plasma Combination Therapies for Treatment of Androgenetic Alopecia: A Systematic Review Journal of Cutaneous and Aesthetic Surgery · 2023
    3. Compliance to Topical Minoxidil and Reasons for Discontinuation Among Patients With Androgenetic Alopecia Dermatology and therapy · 2023
    4. Comparative Efficacy of Topical Finasteride (0.25%) in Combination With Minoxidil (5%) Against 5% Minoxidil or 0.25% Finasteride Alone in Male Androgenetic Alopecia: A Pilot, Randomized Open-Label Study International Journal of Trichology · 2023
    5. Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2021
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    8. The Post-Finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to Endocrine Disruption Current Sexual Health Reports · 2018
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    15. Platelet-Rich Plasma in Androgenic Alopecia: Myth or Effective Tool Journal of Cutaneous and Aesthetic Surgery · 2014
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    19. Topical Finasteride in the Treatment of Androgenic Alopecia: Preliminary Evaluations After a 16-Month Therapy Course Journal of Dermatological Treatment · 1997