The Pharmacokinetics of Topical Finasteride 0.25% Spray in Chinese Adult Male Volunteers with Androgenic Alopecia: A Phase I Study

    February 2025 in “ Advances in Therapy
    Zongguang Tai, Zhen Cui, Xinwei Shi, Haiyan Li, Rongrong Chai, Yanping Huang, Yuanyuan Fang, Dongmei Jia, Quangang Zhu, Zhongjian Chen
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    TLDR The topical finasteride spray was safe and well-tolerated with stable effects.
    This Phase I study assessed the pharmacokinetics, safety, and tolerability of a 0.25% topical finasteride spray in 12 Chinese male volunteers with androgenetic alopecia. Participants applied the spray once daily for 7 days. Results indicated a stable half-life, minimal changes in clearance rate, and approximately twofold accumulation in exposure compared to a single dose. The maximum concentration after 7 days was 29.7 ± 12.9 pg/mL. The treatment was well tolerated, with no significant adverse events reported. The study was ethically approved, funded by Cutia Therapeutics, and supported by the Shanghai Skin Disease Hospital.
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