Evaluation of the Relationship Between Serum G Protein-Coupled Estrogen Receptors (GPER-1) Levels and the Severity and Duration of the Disease in Patients with Androgenetic Alopecia: A Case-Control Study

    Mine Müjde Kuş, Zahide Beril Düzenli, Perihan Öztürk, Ergül Belge Kurutaş
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    TLDR Higher GPER-1 levels are linked to more severe and shorter-duration androgenetic alopecia, suggesting GPER-1 as a potential treatment target.
    This study examined the link between serum G protein-coupled estrogen receptors (GPER-1) levels and the severity and duration of androgenetic alopecia (AGA) in 81 patients (41 men and 40 women) compared to 40 healthy controls. It found that GPER-1 levels were significantly higher in AGA patients than in controls (p < 0.001). There was a negative correlation between GPER-1 levels and disease duration, and a significant relationship between GPER-1 levels and disease severity in both sexes. GPER-1 levels also varied significantly between male and female AGA patients. These results suggest an estrogen-independent role of GPER-1 in AGA pathogenesis, indicating that targeting GPER-1 could be effective in early-stage AGA treatment.
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