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learn HMI-115
 much-hyped research compound targeting prolactin receptor in scalp  
 learn Minoxidil
 An essential vasodilator with some anti-androgenic effects, has excellent safety record  
 learn Metformin
 diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties  
 Research
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  research A Hypothetical Pathogenesis Model for Androgenic Alopecia: Clarifying the Dihydrotestosterone Paradox and Rate-Limiting Recovery Factors
 The model suggests that scalp tension could lead to hair loss, with factors like blood vessel hardening, enlarged oil glands, and poor microcirculation also playing a role. It also hints at a possible link between skull shape and baldness pattern.  
  
  research Pathogenesis of Androgenetic Alopecia
 Androgenetic alopecia, or hair loss, is caused by a mix of genetics, hormones, and environment, where testosterone affects hair growth and causes hair to become smaller and grow for a shorter time.  
  
  research A Genomic Approach to Susceptibility and Pathogenesis Leads to Identifying Potential Novel Therapeutic Targets in Androgenetic Alopecia
 Genomic approach finds new possible treatments for hair loss.  
  
  research Alpha Smooth Muscle Actin Role in Androgenetic Alopecia Pathogenesis
 Reduced alpha smooth muscle actin may cause hair loss in androgenetic alopecia.  
  
  research Regulatory Pathways Implicated in Male Androgenetic Alopecia Pathogenesis
 Genes controlling hair growth and immune response are disrupted in male pattern baldness.  
 Community Join
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  community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment
 The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.  
 community DHT Harms Scalp Microbiome: DHT Itch is REAL
 Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.  
 community IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia
 IGFBP‐rP1 shows potential for treating androgenic alopecia by influencing hair cycle transitions. Increasing IGF-1 levels may have similar effects to Minoxidil and 5-AR inhibitors in reducing hair loss.  
 community Efficacy and Tolerability of N-Acetyl-Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men
 N-Acetyl-Cysteine (NAC) was found to improve hair parameters in men with early-onset androgenetic alopecia, showing increased terminal hair count and decreased vellus hair count, with good tolerability. NAC, used alone or with minoxidil, may help due to its antioxidant properties, though its effectiveness can vary among individuals.  
 community I tried salt water to stop the DHT itch
 Treating the itch associated with male pattern baldness, which is believed to be caused by DHT. Potential treatments discussed include salt water, finasteride, ketoconazole, and RU58841.