Alpha Smooth Muscle Actin Role in Androgenetic Alopecia Pathogenesis

November 2024 in “ Benha Journal of Applied Sciences ”

Rehab Mohammed Salem, Ghada Mohammed Abdel Khalik, Rasha Mahmoud Abdrabbou, Y. A. IBRAHIM

alpha smooth muscle actin androgenetic alopecia hair follicles genetic factors hormonal factors environmental factors α-SMA AGA

TLDR Reduced alpha smooth muscle actin may cause hair loss in androgenetic alopecia.

The study investigates the role of alpha smooth muscle actin (α-SMA) in androgenetic alopecia (AGA), a prevalent form of hair loss. It finds that α-SMA is significantly reduced in the vertex area of AGA patients, which may lead to the loss of structural integrity in hair follicles. This suggests that α-SMA plays a crucial role in the structural changes associated with AGA, highlighting the complex interplay of genetic, hormonal, and environmental factors in its development.

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