Salvianolic Acid B Ameliorates Alopecia by Simultaneously Targeting Wnt/β-Catenin and mTORC2/Akt Signaling

    January 2026 in “ Journal of Dermatological Science ”
    Junjie Cen, Xin Tang, Nan Xu … Miaojian Wan
    Studysummary This research observed that Salvianolic acid B (Sal B) significantly promoted hair regeneration in vivo and in vitro, outperforming minoxidil in a mouse model of androgenetic alopecia, by activating Wnt/β-catenin and mTORC2/Akt pathways and upregulating MMPs and MAPKs.
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    Research cited in this study 19

    1. Ph-Responsive Hydrogel With Dual-Crosslinked Network of Polyvinyl Alcohol/Boric Acid for Controlled Release of Salvianolic Acid B: Novel Pro-Regenerative Mechanisms in Scar Inhibition and Wound Healing Regenerative Biomaterials · 2025
    2. Salvianolic Acid B Reduces Oxidative Stress to Promote Hair Growth in Mice, Human Hair Follicles, and Dermal Papilla Cells Clinical, cosmetic and investigational dermatology · 2024
    3. Justicia Procumbens Prevents Hair Loss in Androgenic Alopecia Mice 2023
    4. Water Extract of Cacumen Platycladi Promotes Hair Growth Through the Akt/GSK3β/β-Catenin Signaling Pathway Frontiers in Pharmacology · 2023
    5. Curcumin-Zinc Framework Encapsulated Microneedle Patch for Promoting Hair Growth Theranostics · 2023
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