Reduced Expression of Vitamin D Receptor Related to Alopecia Universalis by Wnt/B-Catenin Signaling Pathway
TLDR Reduced Vitamin D receptor expression may cause hair loss through the Wnt/b-catenin pathway.
The study explored the relationship between the expression of the Vitamin D receptor (VDR) and alopecia universalis, focusing on the Wnt/b-catenin signaling pathway. It was found that VDR was expressed in the epidermal component of hair follicles and dermal papilla cells, and its absence led to alopecia. The research highlighted that the Wnt/b-catenin signaling pathway was associated with hair growth and structure, suggesting that reduced VDR expression could be linked to alopecia universalis through this pathway.
