Ph-Responsive Hydrogel With Dual-Crosslinked Network of Polyvinyl Alcohol/Boric Acid for Controlled Release of Salvianolic Acid B: Novel Pro-Regenerative Mechanisms in Scar Inhibition and Wound Healing

This study explores a novel pH-responsive hydrogel made from polyvinyl alcohol and boric acid for the controlled release of salvianolic acid B, aimed at reducing scar formation and enhancing skin regeneration. The hydrogel's dual-crosslinked network is highly sensitive to pH, allowing optimal release of the active compound in acidic conditions typical of early wound healing. In vitro tests showed significant inhibition of fibroblast activation and abnormal collagen deposition, preventing excessive scarring. Transcriptome analysis indicated the hydrogel's role in modulating TGF-β and Wnt signaling pathways. In vivo experiments demonstrated improved tissue regeneration, better collagen organization, increased vascularization, and promotion of mature hair follicle development. The hydrogel's biocompatibility and mechanical properties support its potential for clinical use, offering a promising strategy for wound management and scar reduction.