The Role of Wood Sterol in Alopecia Induced by High-Fat Diet Through Lipid Metabolism

May 2024 in “ Food bioscience ”

Ying Wang, Yiwen Guo, Zhu Zhu, Chengyu Zhang, Ziwei Yang, Ming Chang, Yanling Liu

wood sterol alopecia high-fat diet lipid metabolism hair follicle seborrheic alopecia WS HFD

Studysummary In this animal study, mice on a high-fat diet experienced weakened hair follicles but regained hair growth after treatment with wood sterol, which improved hair follicle health and altered hormone levels, suggesting its potential as a preventive measure for diet-induced alopecia. Our plain-language summary of this paper — not a Tressless recommendation.

This study investigated the role of wood sterol (WS) in mitigating hair follicle weakening induced by a high-fat diet (HFD). Optimal crystallization conditions were established to obtain WS with a purity of 96.38% ± 2.89%. Both male and female mice showed a significant increase in hair number following WS intervention, suggesting its potential efficacy in alleviating seborrheic alopecia. The findings highlight WS as a promising natural component for hair loss treatment, with implications for both genders.

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