The Role of Wood Sterol in Alopecia Induced by High-Fat Diet Through Lipid Metabolism

May 2024 in “ Food bioscience ”

Ying Wang, Yiwen Guo, Zhu Zhu, Chengyu Zhang, Ziwei Yang, Ming Chang, Yanling Liu

wood sterol alopecia high-fat diet lipid metabolism hair follicle seborrheic alopecia WS HFD

TLDR Wood sterol may help reduce hair loss caused by a high-fat diet.

This study investigated the role of wood sterol (WS) in mitigating hair follicle weakening induced by a high-fat diet (HFD). Optimal crystallization conditions were established to obtain WS with a purity of 96.38% ± 2.89%. Both male and female mice showed a significant increase in hair number following WS intervention, suggesting its potential efficacy in alleviating seborrheic alopecia. The findings highlight WS as a promising natural component for hair loss treatment, with implications for both genders.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

19 / 19 results

research Stem Cell Applications in Human Hair Growth: A Literature Review

8 citations , April 2023 in “Cureus”

Stem cells could be a better treatment for hair loss by reactivating dormant hair follicles.

research SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes

4 citations , December 2022 in “Advanced science”

SCD1 is important for hair growth by keeping the connection in skin cells where hair stem cells live stable.

research Consumption of Fish Oil High-Fat Diet Induces Murine Hair Loss via Epidermal Fatty Acid Binding Protein in Skin Macrophages

6 citations , December 2022 in “Cell reports”

Eating a high-fat fish oil diet caused mice to lose hair due to a specific immune cell activity in the skin linked to a protein called E-FABP.

research Case Report: A Study of the Clinical Characteristics and Genetic Variants of Post-Finasteride Syndrome Patients

September 2022 in “Translational Andrology and Urology”

Finasteride may cause lasting sexual and mental health issues, and genetic screening could help prevent them.

research Microneedle Mediated Transdermal Delivery of Beta-Sitosterol Loaded Nanostructured Lipid Nanoparticles for Androgenic Alopecia

2 citations , September 2022 in “Drug Delivery”

The microneedle system effectively promotes hair growth for treating androgenic alopecia.

research Sertoli-Leydig Cell Ovarian Tumor: A Rare Cause of Virilization and Androgenic Alopecia

1 citations , August 2022 in “Case Reports”

A rare ovarian tumor caused high testosterone, hair loss, and missed periods, but surgery fixed these issues and led to pregnancy.

research Low-Dose Oral Minoxidil for Treatment of Androgenetic Alopecia and Telogen Effluvium in a Pediatric Population: A Descriptive Study

6 citations , April 2022 in “Journal of The American Academy of Dermatology”

Low-dose oral minoxidil improved hair growth in most pediatric patients with mild side effects.

research Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways

5 citations , March 2022 in “Frontiers in Medicine”

PRP is effective for treating hair loss, especially with other treatments.

research Early Onset Female Pattern Hair Loss: A Case-Control Study for Analyzing Clinical Features and Genetic Variants

3 citations , February 2022 in “Journal of Dermatological Science”

Early onset female hair loss is linked to lower hair density, scalp issues, and certain genetic factors.

research Red Ginseng Oil Promotes Hair Growth and Protects Skin Against UVC Radiation

10 citations , January 2021 in “Journal of Ginseng Research”

Red ginseng oil may help grow hair and protect skin from UVC light.

research Serum 25-Hydroxyvitamin D Levels in Alopecia Areata, Female Pattern Hair Loss, and Male Androgenetic Alopecia in a Chinese Population

4 citations , April 2020 in “Journal of Cosmetic Dermatology”

Low vitamin D levels are linked to different types of hair loss.

research Nonscarring Alopecia in Systemic Lupus Erythematosus: A Cross-Sectional Study with Trichoscopic, Histopathologic, and Immunopathologic Analyses

39 citations , May 2019 in “Journal of the American Academy of Dermatology”

Hair loss in lupus patients indicates higher disease activity.

research Efficacy of Pine Needle Extract in a Rat Model of Androgenic Alopecia

1 citations , February 2019 in “Nanoscience and Nanotechnology Letters”

research Characteristic Findings by Phototrichogram in Southern Chinese Women with Female Pattern Hair Loss

10 citations , January 2019 in “Skin Research and Technology”

Southern Chinese women with female pattern hair loss have less, thinner hair and smaller hair follicles.

research Inhibition of Glycosphingolipid Synthesis Reverses Skin Inflammation and Hair Loss in ApoE−/− Mice Fed Western Diet

30 citations , July 2018 in “Scientific Reports”

Blocking certain fat production can reverse skin inflammation and hair loss.

research Clinical Efficacy of Oral Administration of Finasteride at a Dose of 2.5 mg/Day in Women with Female Pattern Hair Loss

13 citations , February 2018 in “Dermatologic Therapy”

Finasteride 2.5 mg/day can effectively treat female hair loss.

research Hair Growth Promoting Effect of White Wax and Policosanol from White Wax on the Mouse Model of Testosterone-Induced Hair Loss

27 citations , February 2017 in “Biomedicine & Pharmacotherapy”

White wax and policosanol from white wax effectively reduced hair loss and promoted hair growth in mice better than a known hair growth drug.

research Stimulatory Effect of Brazilian Propolis on Hair Growth Through Proliferation of Keratinocytes in Mice

18 citations , November 2014 in “Journal of Agricultural and Food Chemistry”

Brazilian propolis was found to speed up hair growth in mice by increasing the growth of skin cells that form hair.

research Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia

59 citations , May 2014 in “Expert Opinion on Therapeutic Targets”

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Similar Research

5 / 1000+ results

research Acyl-CoA Binding Protein and Epidermal Barrier Function

15 citations , March 2014 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

ACBP is essential for healthy skin and fur by maintaining the skin's barrier function.

research Nutritional and Microbial Strategies for Treating Acne, Alopecia, and Atopic Dermatitis

15 citations , October 2024 in “Nutrients”

A plant-based diet and certain probiotics may improve skin health and reduce inflammation.

research Metabolic Syndrome and Skin Diseases

40 citations , November 2019 in “Frontiers in Endocrinology”

Metabolic Syndrome is linked to several skin conditions, and stem cell therapy might help treat them.

research Ethnopharmacological Significance of Eclipta Alba (L.) Hassk. (Asteraceae)

49 citations , October 2014 in “International Scholarly Research Notices”

Eclipta alba has many health benefits and contains compounds with potential for drug development.

research Linking Diet to Acne Metabolomics, Inflammation, and Comedogenesis: An Update

138 citations , July 2015 in “Clinical, Cosmetic and Investigational Dermatology”

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.