Diet-Induced Obesity Promotes Alopecia Through Oxidative Stress and Androgen Signaling in Female Mice

    August 2026 in “ Experimental Dermatology ”
    Yi‐An Tu, Chia‐Hung Chou, Koping Chang … Mei‐Jou Chen
    Studysummary This study found that a high-fat diet exacerbates hair loss in female mice by increasing oxidative stress and androgen signaling in the skin, and that treatments with antioxidants or antiandrogens may help mitigate this effect.
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    Research cited in this study 18

    1. LH Induces Murine Hair Loss Through TRPC-Mediated Cell Aging Responses: Implications for Female Pattern Hair Loss Pathogenesis Journal of Investigative Dermatology · 2025
    2. The Quality of Life and Psychosocial Impact on Female Pattern Hair Loss Annals of Dermatology · 2024
    3. Polycystic Ovary Syndrome and Oxidative Stress: From Bench to Bedside International journal of molecular sciences · 2023
    4. Female Pattern Hair Loss and Negative Psychological Impact: Possible Role of Brain-Derived Neurotrophic Factor Dermatology practical & conceptual · 2023
    5. Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics Journal of Clinical Medicine · 2023
    6. Consumption of Fish Oil High-Fat Diet Induces Murine Hair Loss via Epidermal Fatty Acid Binding Protein in Skin Macrophages Cell reports · 2022
    7. Obesity and Polycystic Ovary Syndrome Clinical Endocrinology · 2021
    8. Structure of Human Steroid 5α-Reductase 2 with the Anti-Androgen Drug Finasteride Nature Communications · 2020
    9. HSD3B1 Gene Polymorphism and Female Pattern Hair Loss in Women with Polycystic Ovary Syndrome Journal of the Formosan Medical Association · 2019
    10. Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee The Journal of Clinical Endocrinology and Metabolism · 2019
    11. Female Pattern Hair Loss: A Clinical, Pathophysiologic, and Therapeutic Review International Journal of Women's Dermatology · 2018
    12. Reversal of the Hair Loss Phenotype by Modulating the Estradiol-ANGPT2 Axis in the Mouse Model of Female Pattern Hair Loss Journal of Dermatological Science · 2018
    13. Androgens Trigger Different Growth Responses in Genetically Identical Human Hair Follicles in Organ Culture Reflecting Their Epigenetic Diversity in Life The FASEB Journal · 2017
    14. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
    15. Association of Metabolic Syndrome With Female Pattern Hair Loss in Women: A Case-Control Study International Journal of Dermatology · 2016
    16. Female Pattern Hair Loss: A Review Article international journal of endocrinology and metabolism · 2013
    17. Increased Androgen Receptor Messenger RNA in Frontal-Parietal Hair Follicles of Women with Androgenetic Alopecia Genetics and Molecular Research · 2013
    18. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology & Metabolism · 2008