August 2026 in “Experimental Dermatology” This study found that a high-fat diet exacerbates hair loss in female mice by increasing oxidative stress and androgen signaling in the skin, and that treatments with antioxidants or antiandrogens may help mitigate this effect.
This study found that a high-fat diet in macaques led to severe gastrointestinal inflammation and chronic wasting, with more pronounced effects in females, highlighting the potential risks of certain dietary interventions in obesity models.
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August 2018 in “Journal of Lipid Research” This study observed that partial autotaxin deficiency in mice protects against diet-induced obesity and systemic insulin resistance, suggesting the ATX-LPA pathway negatively affects skeletal muscle insulin signaling and mitochondrial function during obesity.
January 2022 in “World journal of pharmaceutical sciences” This review discusses methods for inducing polycystic ovary syndrome in animal models, with letrozole considered the easiest and most convenient for testing new treatments, but it reports no new clinical findings.
April 2017 in “Journal of Investigative Dermatology” This study suggests that PKCß plays a critical role in modulating the dermal inflammatory microenvironment in response to dietary lipids in mice.