Exploring the Role of Dermal Sheath Cells in Wound Healing and Fibrosis

    June 2024 in “ Preprints.org ”
    Bing Zhu, Lu Liang, Lihua Hui, Yaojun Lu

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This review explores the roles of dermal sheath cells in wound healing, highlighting their multifunctional contributions to inflammation, proliferation, and extracellular matrix remodeling, and proposes new insights into tissue regeneration and repair, especially in differentiating between hairy and non-hairy skin sites.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on preprints.org →
    Discuss this study in the Community →

    Research cited in this study 25

    1. Exploring the Role of Dermal Sheath Cells in Wound Healing and Fibrosis Preprints.org · 2024
    2. Progenitor-Derived Endothelin Controls Dermal Sheath Contraction for Hair Follicle Regression Nature cell biology · 2023
    3. Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation Biomedicines · 2022
    4. Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype Frontiers in Genetics · 2022
    5. Fibroblasts: Origins, Definitions, and Functions in Health and Disease Cell · 2021
    6. Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging Journal of Investigative Dermatology · 2020
    7. Immune Modulation of Hair Follicle Regeneration npj Regenerative Medicine · 2020
    8. Regeneration of Dermis: Scarring and Cells Involved Cells · 2019
    9. Injury Modifies the Fate of Hair Follicle Dermal Stem Cell Progeny in a Hair Cycle-Dependent Manner Experimental dermatology · 2019
    10. Skin Cell Heterogeneity in Development, Wound Healing, and Cancer Trends in cell biology · 2018
    11. Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles Acta dermato-venereologica · 2018
    12. Multifaceted Role of Hair Follicle Dermal Cells in Bioengineered Skins British journal of dermatology/British journal of dermatology, Supplement · 2016
    13. Dermal Sheath Cells Contribute to Postnatal Hair Follicle Growth and Cycling Journal of Dermatological Science · 2016
    14. Fate of Prominin-1 Expressing Dermal Papilla Cells During Homeostasis, Wound Healing, and Wnt Activation Journal of Investigative Dermatology · 2015
    15. In Vitro Characterization of Human Hair Follicle Dermal Sheath Mesenchymal Stromal Cells and Their Potential in Enhancing Diabetic Wound Healing Cytotherapy · 2015
    16. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    17. BMP-FGF Signaling Axis Mediates Wnt-Induced Epidermal Stratification in Developing Mammalian Skin PLoS Genetics · 2014
    18. Reflections on How Wound Healing-Promoting Effects of the Hair Follicle Can Be Translated into Clinical Practice Experimental Dermatology · 2014
    19. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    20. Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing Development · 2013
    21. De Novo Production of Dermal Papilla Cells During the Anagen Phase of the Hair Cycle Journal of Investigative Dermatology · 2010
    22. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    23. Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme: Implications for Hair Growth Control Journal of Investigative Dermatology · 2003
    24. Histological and Immunohistochemical Studies of Excisional Wounds in Rats: The Role of Hair Follicles in Wound Healing Durham e-Theses (Durham University) · 2000
    25. The Upper Dermal Sheath Has Potential to Regenerate Hair in Rat Follicular Epidermis Differentiation · 1996