A Human Folliculoid Microsphere Assay for Exploring Epithelial-Mesenchymal Interactions in the Human Hair Follicle

    October 2008 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Blanka Havlíčková, Tamás Bı́ró, Alessandra Mescalchin … Ralf Paus
    Studysummary This study presents a novel in vitro assay using human folliculoid microspheres to research hair growth, which may facilitate preclinical testing of hair growth-modulatory agents.
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    Research cited in this study 37

    1. The Hair Follicle as an Estrogen Target and Source Endocrine Reviews · 2006
    2. Induction of Versican by Ascorbic Acid 2-Phosphate in Dermal Papilla Cells Journal of Dermatological Science · 2006
    3. Therapeutic Strategies for Treating Hair Loss Drug Discovery Today: Therapeutic Strategies · 2006
    4. Substantial Sex-Dependent Differences in the Response of Human Scalp Hair Follicles to Estrogen Stimulation In Vitro Advocate Gender-Tailored Management of Female Versus Male Pattern Balding Journal of Investigative Dermatology Symposium Proceedings · 2005
    5. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    6. Reorganization of Hair Follicles in Human Skin Organ Culture Induced by Cultured Human Follicle-Derived Cells Experimental Dermatology · 2005
    7. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    8. Estrogen Functions in Skin and Skin Appendages Expert Opinion on Therapeutic Targets · 2005
    9. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005
    10. Hair Cycle-Specific Expression of Versican in Human Hair Follicles Journal of Dermatological Science · 2005
    11. Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression Journal of Investigative Dermatology · 2005
    12. Keratins of the Human Hair Follicle International review of cytology · 2005
    13. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    14. Progressive Hair Loss And Myocardial Degeneration In Rough Coat Mice: Reduced Lysyl Oxidase-Like (LOXL) In The Skin And Heart Journal of Investigative Dermatology · 2004
    15. Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia Journal of Investigative Dermatology · 2004
    16. Dermal Papilla-Induced Hair Differentiation of Adult Epithelial Stem Cells from Human Skin Physiological Genomics · 2004
    17. Different Gene Expression Profile Observed in Dermal Papilla Cells Related to Androgenic Alopecia by DNA Macroarray Analysis Journal of Dermatological Science · 2004
    18. Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    19. Vitamin D3 Analogs Stimulate Hair Growth in Nude Mice Endocrinology · 2002
    20. Simple and Rapid Method to Isolate and Culture Follicular Papillae from Human Scalp Hair Follicles Experimental Dermatology · 2002
    21. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    22. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001
    23. Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells Journal of Investigative Dermatology · 2001
    24. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    25. Current Understanding of Androgenetic Alopecia: Part II: Clinical Aspects and Treatment PubMed · 2000
    26. Current Understanding of Androgenetic Alopecia: Part I - Etiopathogenesis PubMed · 2000
    27. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    28. Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    29. Regulation of Human Dermal Papilla Cell Production of Insulin-Like Growth Factor Binding Protein-3 by Retinoic Acid, Glucocorticoids, and Insulin-Like Growth Factor-1 Journal of cellular physiology · 1996
    30. Effects of Hypertrichotic Agents on Follicular and Nonfollicular Cells In Vitro Skin Pharmacology and Physiology · 1996
    31. Biphasic Effect of 1,25-Dihydroxyvitamin D3 on Human Hair Follicle Growth and Hair Fiber Production in Whole-Organ Cultures ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    32. Outer Root Sheath Cells Organize Into Epidermoid Cyst-Like Spheroids When Cultured Inside Matrigel: A Light-Microscopic and Immunohistological Comparison Between Human ORS Cells and Interfollicular Keratinocytes Cell and Tissue Research · 1994
    33. Organotypic Cocultures as Models to Study Cell-Cell and Cell-Matrix Interactions of Human Hair Follicle Cells Skin Pharmacology and Physiology · 1994
    34. Soluble Factors From Human Hair Papilla Cells And Dermal Fibroblasts Dramatically Increase The Clonal Growth Of Outer Root Sheath Cells Archives of Dermatological Research · 1993
    35. Skin Toxicity Determined In Vitro By Three-Dimensional, Native-State Histoculture Proceedings of the National Academy of Sciences · 1991
    36. Human Hair Growth In Vitro Journal of Cell Science · 1990
    37. The In Vitro Properties of Dermal Papilla Cell Lines Established From Human Hair Follicles British Journal of Dermatology · 1986

    Related research 5

    1. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006
    2. Reorganization of Hair Follicles in Human Skin Organ Culture Induced by Cultured Human Follicle-Derived Cells Experimental Dermatology · 2005
    3. Study on Hair Follicle Formation Induced by Dermal Papilla Cells Chinese Journal of Reparative and Reconstructive Surgery · 2003
    4. Hair Matrix Germinative Epidermal Cells Confer Follicle-Inducing Capabilities on Dermal Sheath and High Passage Papilla Cells Development · 1996
    5. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994