TLDR The gene causing hair loss and heart issues in rough coat mice is still unknown.
The study examined rough coat (rc) mice, which experienced progressive hair loss and myocardial degeneration, focusing on the lysyl oxidase-like (LOXL) gene due to its reduced expression in affected tissues. Despite decreased LOXL levels in the skin and heart, no mutations were found in the loxl gene, indicating it was not the direct cause of the rc phenotype. The study involved 129 F2 backcross animals and monitored 24 rc/rc mice for body weight over 17 weeks. The findings suggested that while LOXL reduction might contribute to extracellular matrix abnormalities, the gene responsible for the rc phenotype remained unidentified, requiring further investigation.
26 citations
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December 1999 in “Journal of Investigative Dermatology” Certain genes are linked to wool follicle structure and function, but not hair cycle regulation.
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Retinoids can change the hair growth cycle by extending the growth phase and shortening the rest phase.
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October 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” HFMs can help study hair growth and test potential hair growth drugs.
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14 citations
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May 2013 in “American Journal of Physiology-endocrinology and Metabolism” Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.
