Elastogenesis Stimulation by Minoxidil or Nebivolol Reduces Premature Aging of the Aortic Wall in Diabetic Mice

    April 2024
    Aubéri Henry, Laetitia Vanalderwiert, Amandine Wahart, Daniel A. Carvajal Berrio, Eva Brauchle, Katja Schenke‐Layland, Juergen Brinckmann, Heiko Steenbock, Laurent Debelle, Isabelle Six, Gilles Faury, Stéphane Jaisson, Philippe Gillery, Vincent Durlarch, Hervé Sartelet, Pascal Maurice, Amar Bennasroune, Laurent Martiny, Laurent Duca, Béatrice Romier, Sébastien Blaise
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    Studysummary This study in diabetic db/db mice found that treatment with the antihypertensive agents minoxidil or nebivolol stimulated elastogenesis and inhibited elastolysis, leading to restored elastic fibers, reduced aortic stiffening, and normalized blood pressure.
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    The study investigates the effects of minoxidil and nebivolol on elastogenesis and elastolysis in diabetic db/db mice, aiming to reduce premature aging of the aortic wall. By treating these mice with the antihypertensive agents, researchers observed stimulation of elastogenesis and inhibition of elastolysis, which restored functional elastic fibers and brought blood pressure levels closer to normal. The treatments work by opening ATP-sensitive potassium channels and regulating the forkhead box transcription factor (FOXO1). The findings suggest that monitoring these pathways could help limit aortic aging and reduce hypertension, atherosclerosis, and aneurysms in diabetic patients.
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