Identification of Differentially Expressed Genes During a Wool Follicle Growth Cycle Induced by Prolactin

December 1999 in “ Journal of Investigative Dermatology ”

Nicholas Rufaut, A.J. Pearson, A. J. Nixon, Thomas T. Wheeler, Richard J. Wilkins

prolactin wool follicle KRTAP3.2 desmoglein 1 stratifin Clk3 telogen phase anagen phase follicle structure cell cycling differentiation RNA splicing

TLDR Certain genes are linked to wool follicle structure and function, but not hair cycle regulation.

The study examined gene expression changes during wool follicle growth cycles in New Zealand Wiltshire sheep, induced by prolactin manipulation. Using differential display, researchers identified nine differentially expressed genes, with four known genes: KRTAP3.2, desmoglein 1, stratifin, and Clk3. These genes were downregulated in the telogen phase compared to anagen, indicating their roles in follicle structure and function. Stratifin was linked to cell cycling and differentiation, while Clk3 was involved in RNA splicing. The study demonstrated the effectiveness of differential display in identifying genes related to follicle function, though these genes were not likely to regulate the hair cycle itself.

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research Vesicle Formation and Follicular Root Sheath Separation in Mice Homozygous for Deleterious Alleles at the Balding Locus

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