Potential Involvement Of miR-144 In The Regulation Of Hair Follicle Development And Cycle Through Interaction With Lhx2

The study examines the role of microRNA-144 (miR-144) in hair follicle development and cycling by targeting the Lhx2 gene in Cashmere goats. It identifies three potential target sites for miR-144 on the Lhx2 3′ UTR, showing that miR-144 binding reduces Lhx2 expression, which affects dermal papilla cells' regulation of hair matrix cell proliferation and differentiation. This interaction impacts cashmere wool growth and suggests that miR-144's regulation of Lhx2 could lead to advancements in cashmere production and treatments for hair growth disorders. The study highlights miR-144's potential as a therapeutic target for hair growth and alopecia treatment.