Hair Follicle-Inspired Therapies for Wound Healing and Scar Remodeling

    July 2025 in “ Journal of Plastic Reconstructive & Aesthetic Surgery ”
    Monica Chew, Summik Limbu, Paul Kemp, Claire A. Higgins
    Studysummary This review discusses the role of hair follicles in wound healing and scar remodeling, emphasizing that hair follicle transplantation may aid in faster wound closure and scar reduction by enhancing the cellular and molecular mechanisms involved in scarring.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 22

    1. Single-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair Advances in Wound Care · 2025
    2. Hair Follicle Punch Grafts in Hard-To-Heal Wounds: A Monocenter Study and Patient Survey Health Science Reports · 2024
    3. Stem Cell Therapy Prior to Follicular Unit Hair Transplantation on Scarred Tissue: A Novel Approach to a Successful Procedure PubMed · 2024
    4. FUE as the First Surgical Option for Hair Reconstruction on Scalp and Facial Skin Grafts – Case Report Journal of Medicine and Life · 2024
    5. Anagen Hair Follicles Transplanted Into Mature Human Scars Remodel Fibrotic Tissue npj regenerative medicine · 2023
    6. Extracellular Vesicles From 3D Cultured Dermal Papilla Cells Improve Wound Healing Via Krüppel-Like Factor 4/Vascular Endothelial Growth Factor A-Driven Angiogenesis Burns and trauma · 2023
    7. Head and Neck Restoration in Scar Alopecia: Hair Transplantation in Scalp, Eyebrows, Beard, and Mustache World journal of plastic surgery · 2021
    8. Treatment of Postsurgical Scalp Scar Deformity Using Follicular Unit Hair Transplantation BioMed Research International · 2019
    9. Distinct Patterns of Hair Graft Survival After Transplantation Into Two Nonhealing Ulcers: Is Location Everything? Dermatologic Surgery · 2019
    10. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    11. Multifaceted Role of Hair Follicle Dermal Cells in Bioengineered Skins British journal of dermatology/British journal of dermatology, Supplement · 2016
    12. In Vitro Characterization of Human Hair Follicle Dermal Sheath Mesenchymal Stromal Cells and Their Potential in Enhancing Diabetic Wound Healing Cytotherapy · 2015
    13. Effect of Discarded Keratin-Based Biocomposite Hydrogels on the Wound Healing Process In Vivo Materials Science and Engineering C · 2015
    14. Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells Stem Cells Translational Medicine · 2014
    15. Reflections on How Wound Healing-Promoting Effects of the Hair Follicle Can Be Translated into Clinical Practice Experimental Dermatology · 2014
    16. Hair Follicle Transplantation on Scar Tissue Journal of Craniofacial Surgery · 2013
    17. A Pilot Clinical Study of Hair Grafting in Chronic Leg Ulcers Wound Repair and Regeneration · 2012
    18. Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents Journal of Investigative Dermatology · 2007
    19. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    20. Single-Follicular-Unit Hair Transplantation to Correct Cleft Lip Moustache Alopecia The Cleft Palate Craniofacial Journal · 2001
    21. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    22. Successful Treatment of Chronic Leg Ulcers with Epidermal Equivalents Generated from Cultured Autologous Outer Root Sheath Cells Journal of Investigative Dermatology · 1996