Distinct Patterns of Hair Graft Survival After Transplantation Into Two Nonhealing Ulcers: Is Location Everything?

The study investigated the effects of hair follicle transplantation on nonhealing ulcers, focusing on scar formation and hair growth. Hair follicles were transplanted from the scalp into the ulcers, resulting in rapid wound closure. Notably, the periphery of the wounds healed with an almost scarless appearance and no hair shaft survival, while the center developed a fibrotic scar with some hair growth. In situ analyses showed differences in dermal remodeling and collagen formation between the central and peripheral areas of the scars. The findings confirmed the therapy's effectiveness in promoting wound healing and suggested that location-dependent differences in scar quality and hair growth might be influenced by mechanical forces or wound microenvironments.