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    Spatiotemporal Secondary Hair Follicle Development in the Lanyu Pig: A Novel Pelage Hair Follicle Model

    August 2026 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Chein-Hong Lin, Ting-Yung Kuo, Yuan‐Yu Hsueh … Michael W. Hughes

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study characterizes the secondary hair follicles in the Lanyu pig, an indigenous breed sharing similarities with human vellus hair follicles, suggesting its relevance as a model for researching hair follicle-mediated skin regeneration and enhancing translation to human wound healing.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 18

    1. Apoptotic Cells Represent a Dynamic Stem Cell Niche Governing Proliferation and Tissue Regeneration Developmental Cell · 2021
    2. Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice Nature Communications · 2021
    3. Comparative Regenerative Biology of Spiny (Acomys Cahirinus) and Laboratory (Mus Musculus) Mouse Skin Experimental Dermatology · 2019
    4. Regeneration of Rete Ridges in Lanyu Pig (Sus Scrofa): Insights for Human Skin Wound Healing Experimental Dermatology · 2019
    5. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018
    6. Msx2 Supports Epidermal Competency During Wound-Induced Hair Follicle Neogenesis Journal of Investigative Dermatology · 2018
    7. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    8. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    9. Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations Cell · 2015
    10. The Immunology of the Porcine Skin and Its Value as a Model for Human Skin Molecular immunology · 2014
    11. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    12. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    13. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    14. Hair Follicles and Their Role in Skin Health Expert Review of Dermatology · 2006
    15. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    16. Location and Phenotype of Human Adult Keratinocyte Stem Cells of the Skin Differentiation · 2004
    17. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    18. The Biology of Hair Follicles The New England Journal of Medicine · 1999