Preparation and Characterization of Dutasteride-Loaded Nanostructured Lipid Carriers Coated with Stearic Acid-Chitosan Oligomer for Topical Delivery

April 2017 in “ European Journal of Pharmaceutics and Biopharmaceutics ”

Norhayati Mohamed Noor, Khalid Sheikh, Satyanarayana Somavarapu, Kevin Taylor

dutasteride nanostructured lipid carriers stearic acid chitosan oligomer topical delivery hair follicles systemic effects particle size surface charge in vitro release pig ear skin systemic absorption cytotoxicity nanoparticles hair growth promotion Avodart NLCs CSO-SA

Studysummary This study found that dutasteride-loaded nanostructured lipid carriers coated with a stearic acid-chitosan oligomer are stable, less cytotoxic, and suitable for topical delivery to promote hair growth.

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