Vitamin E Promotes Dermal Papilla Cell Proliferation Via The LncRNA2919/STAT1 Axis To Activate The Hedgehog Signaling Pathway

    August 2026 in “ Non-coding RNA Research ”
    Yinuo Fang, Sen Wang, Chengpeng Cao … Yang Chen
    Studysummary The study reports that vitamin E improves hair-follicle growth and dermal papilla cell proliferation in vitro by modulating the lncRNA2919/STAT1/SHH axis in Angora rabbits, enhancing cellular antioxidant capacity.
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    Research cited in this study 20

    1. Pathophysiological Mechanisms of Hair Follicle Regeneration and Potential Therapeutic Strategies Stem Cell Research & Therapy · 2025
    2. Circ 0020938 Inhibits Hair Follicle Stem Cells Proliferation via the miR-142-5p/DSG4 Axis in Cashmere Goats BMC Genomics · 2025
    3. JAK-STAT1 as Therapeutic Target for EGFR Deficiency-Associated Inflammation and Scarring Alopecia EMBO Molecular Medicine · 2024
    4. Oxidative Stress in Hair Follicle Development and Hair Growth: Signaling Pathways, Intervening Mechanisms and Potential of Natural Antioxidants Journal of Cellular and Molecular Medicine · 2024
    5. DNA Methylation Mediates LncRNA2919 Regulation of Hair Follicle Regeneration International Journal of Molecular Sciences · 2022
    6. LncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via Trans-Regulatory Actions Cells · 2022
    7. Electrical Stimulation to Human Dermal Papilla Cells for Hair Regenerative Medicine Journal of Bioscience and Bioengineering · 2022
    8. LncRNA-PCAT1 Maintains Characteristics of Dermal Papilla Cells and Promotes Hair Follicle Regeneration by Regulating miR-329/Wnt10b Axis Experimental Cell Research · 2020
    9. LncRNA-XIST Promotes Dermal Papilla Induced Hair Follicle Regeneration by Targeting miR-424 to Activate Hedgehog Signaling Cellular Signalling · 2020
    10. Hes1 Regulates Anagen Initiation and Hair Follicle Regeneration Through Modulation of Hedgehog Signaling Stem Cells · 2019
    11. Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing Frontiers in genetics · 2019
    12. An Integrated Analysis of Cashmere Fineness lncRNAs in Cashmere Goats Genes · 2019
    13. LncRNA-000133 from Secondary Hair Follicle of Cashmere Goat: Identification, Regulatory Network, and Its Effects on Inductive Property of Dermal Papilla Cells Animal Biotechnology · 2019
    14. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    15. Hair Biology Facial Plastic Surgery Clinics of North America · 2018
    16. The Hair Follicle: Functions, Self-Renewal, and Alopecic Disorders Toxicologic pathology · 2016
    17. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    18. Oxidative Stress in Alopecia Areata: A Case-Control Study American Journal of Clinical Dermatology · 2013
    19. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    20. Antioxidants and Lipid Peroxidation Status in the Blood of Patients with Alopecia Cell biochemistry and function · 2000