Integrating Evidence-Based Lifestyle and Adjunct Therapies for Long-Term Management of Polycystic Ovary Syndrome: Mechanistic Insights and Clinical Implications

    May 2026 in “ Frontiers in Reproductive Health ”
    Prasanth Babu Nandagopal, Gopika Jayakrishnan, Anu Varghese Kaithamattathil, Venkatraman Manickam
    Studysummary This narrative review reported that a variety of lifestyle-based interventions, such as specific dietary changes and physical activity, along with adjunctive therapies, have potential benefits in managing metabolic and hormonal outcomes in women with PCOS, although the variable study quality suggests further research is needed.
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    Research cited in this study 16

    1. The Effectiveness of Nutritional Supplements in Improving Polycystic Ovary Syndrome in Women: A Systematic Review and Network Meta-Analysis Reproductive Biology and Endocrinology · 2025
    2. The Influence of Physical Activity, Diet, and Lifestyle of Patients on the Course of Polycystic Ovary Syndrome in Women Quality in Sport · 2024
    3. Exercise in the Management of Polycystic Ovary Syndrome: A Position Statement from Exercise and Sports Science Australia Journal of science and medicine in sport · 2024
    4. Effectiveness of Mentha Spicata Leaves in Reducing Testosterone Levels and Aggressive Behavior in Female Wistar Albino Rats Treated with Testosterone Propionate Journal of Applied and Natural Science · 2024
    5. Alternative Treatment of Polycystic Ovary Syndrome: Pre-Clinical and Clinical Basis for Using Plant-Based Drugs Frontiers in Endocrinology · 2024
    6. Depression in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Journal of clinical medicine · 2023
    7. Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics Journal of Clinical Medicine · 2023
    8. A Practical Approach to the Management of Hair Loss in Patients With Polycystic Ovary Syndrome Journal of the European Academy of Dermatology and Venereology · 2023
    9. Quercetin and Polycystic Ovary Syndrome Frontiers in Pharmacology · 2022
    10. An Update of Polycystic Ovary Syndrome: Causes and Therapeutic Options Heliyon · 2022
    11. The Challenging Role of Antiandrogens in the Management of Polycystic Ovary Syndrome Elsevier eBooks · 2021
    12. A Systematic Review of the Effects of Exercise on Hormones in Women with Polycystic Ovary Syndrome Journal of Functional Morphology and Kinesiology · 2020
    13. The Mechanism of Androgen Actions in PCOS Etiology Medical Sciences · 2019
    14. Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies Clinical medicine insights · 2019
    15. Polycystic Ovary Syndrome: Etiology, Pathogenesis, and Diagnosis Nature Reviews Endocrinology · 2011
    16. Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive, and Metabolic Manifestations That Impacts Health Across the Lifespan BMC Medicine · 2010