The Effectiveness of Nutritional Supplements in Improving Polycystic Ovary Syndrome in Women: A Systematic Review and Network Meta-Analysis

This systematic review and network meta-analysis assessed the effectiveness of nutritional supplements in improving polycystic ovary syndrome (PCOS) symptoms in women, analyzing data from 79 randomized controlled trials with 5,501 participants. The study found that chromium, inositol, and omega-3 were effective in improving lipid profiles and reducing insulin resistance. Chromium also improved follicle-stimulating hormone levels and antioxidant capacity, while soy isoflavones reduced oxidative stress. Inositol decreased cholesterol and triglyceride levels, and curcumin improved cholesterol profiles. The study concluded that these supplements could serve as adjunctive therapy for managing PCOS, though it highlighted the need for more direct comparisons and large-scale trials to confirm these findings.