Skin Transcriptome Reveals the Periodic Changes in Genes Underlying Hair Follicle Cycling in Cashmere Goats

February 2019 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Zhihong Liu, Feng Yang, Meng Zhao, Qing Mu, Tianyu Che, Yuchun Xie, Lina Ma, Lu Mi, Rui Su, Yanjun Zhang, Ruijun Wang, Zhiying Wang, Yanhong Zhao, Jinquan Li

hair follicle cycling transcriptome sequencing fluorescence quantitative PCR KAP3.1 KRTAP 8-1 KRTAP 24-1

TLDR Cashmere goat hair growth follows a cycle with distinct growth, regression, and resting periods, influenced by specific genes.

This study investigated the molecular regulation mechanisms of the secondary hair follicle growth cycle in Inner Mongolia cashmere goats using transcriptome sequencing and fluorescence quantitative PCR. The research identified three distinct periods in the cashmere hair growth cycle: growth (March-September), regression (September-December), and resting (December-March). March marked the beginning of the cycle with the most significant gene expression differences. Key genes such as KAP3.1, KRTAP 8-1, and KRTAP 24-1 showed a positive correlation with the growth cycle, with their expression sequence indicating a regulatory pattern consistent with the cashmere growth cycle.

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