Role of Estrogen Receptor Signaling in the Control of the Hair Follicle Cycle

    January 2004
    Franziska Conrad
    Studysummary In this study, researchers observed that estrogen and its receptors play a crucial role in hair growth and control, with notable sex-dependent differences in human scalp hair follicles.
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    Research cited in this study 37

    1. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006
    2. Topical Estrogen Accelerates Hair Regrowth in Mice After Chemotherapy-Induced Alopecia by Favoring the Dystrophic Catagen Response Pathway to Damage Journal of Investigative Dermatology · 2004
    3. Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles Journal of Investigative Dermatology · 2003
    4. Substance P Prolongs Human Hair Growth In Vitro Journal of dermatological science · 2003
    5. Scalp Hair Diameter Increases During Pregnancy Clinical and Experimental Dermatology · 2003
    6. Molecular Biology of Hair Morphogenesis: Development and Cycling Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution · 2003
    7. The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit Journal of Investigative Dermatology Symposium Proceedings · 2003
    8. Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen American Journal of Pathology · 2003
    9. Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology Journal of Investigative Dermatology · 2003
    10. Estrogen Receptor Alpha, But Not Estrogen Receptor Beta, Is Involved in the Regulation of Hair Follicle Cycling and Epidermis Thickness in Male Mice Journal of Investigative Dermatology · 2002
    11. Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth ˜The œFASEB journal · 2002
    12. 17α-Estradiol Induces Aromatase Activity in Intact Human Anagen Hair Follicles Ex Vivo Experimental Dermatology · 2002
    13. 17β-Estradiol Enhances Vascular Endothelial Growth Factor Production and Dihydrotestosterone Antagonizes the Enhancement via the Regulation of Adenylate Cyclase in Differentiated THP-1 Cells ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    14. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    15. Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla Journal of Investigative Dermatology · 2001
    16. Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin The FASEB Journal · 2001
    17. Influence of Estrogens on Androgen Metabolism in Different Subunits of Human Hair Follicles PubMed · 2001
    18. 17β-Estradiol and ICI-182780 Regulate the Hair Follicle Cycle in Mice Through an Estrogen Receptor-α Pathway Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism · 2000
    19. Intracrinology and the Skin Hormone Research in Paediatrics · 2000
    20. In Vitro Main Pathways of Steroid Action in Cultured Hair Follicle Cells: Vascular Approach Journal of Investigative Dermatology Symposium Proceedings · 1999
    21. Effects of 17-β-Estradiol and ICI 182 780 on Hair Growth in Various Strains of Mice Journal of Investigative Dermatology Symposium Proceedings · 1999
    22. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    23. What Controls Hair Follicle Cycling? Experimental dermatology · 1999
    24. A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    25. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    26. Clinical Updates in Hair Dermatologic Clinics · 1997
    27. An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation Proceedings of the National Academy of Sciences of the United States of America · 1996
    28. Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells Biochemical and biophysical research communications · 1995
    29. Interaction Between Dermal Papilla Cells and Follicular Epithelial Cells In Vitro: Effect of Androgen PubMed · 1995
    30. Hair Follicle Stem Cells: Their Location, Role in Hair Cycle, and Involvement in Skin Tumor Formation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    31. Dermal-Epidermal Interactions: Follicle Derived Cell Populations in the Study of Hair Growth Mechanisms ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    32. The Secret Life of the Hair Follicle Trends in genetics · 1992
    33. Diseases of the Hair and Scalp Medical Entomology and Zoology · 1991
    34. Human Hair Growth In Vitro Journal of Cell Science · 1990
    35. Effects of Epidermal Growth Factor on Hair Growth in the Mouse Journal of Endocrinology · 1981
    36. Growth of the Hair Physiological Reviews · 1954
    37. The Endocrine System and Hair Growth in the Rat Journal of Endocrinology · 1942

    Related research 12

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    2. Mesenchymal-Epidermal Interactions in Hair Follicle Cycling and Regeneration 2015
    3. Dietary Vitamin A Regulates Wingless-Related MMTV Integration Site Signaling to Alter the Hair Cycle Experimental Biology and Medicine · 2014
    4. A Role of Placental Growth Factor in Hair Growth Journal of dermatological science · 2014
    5. Dynamic Wnt5a Expression in Murine Hair Follicle Cycle and Its Inhibitory Effects on Follicular Growth Asian Pacific journal of tropical medicine · 2014
    6. Cutaneous Retinoic Acid Levels Determine Hair Follicle Development And Downgrowth Journal of biological chemistry/˜The œJournal of biological chemistry · 2012
    7. Mimicking Hair Disorders by Genetic Manipulation of Organ-Cultured Human Hair Follicles Journal of Investigative Dermatology · 2012
    8. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    9. Cutaneous Consequences of Inhibiting EGF Receptor Signaling In Vivo: Normal Hair Follicle Development, But Retarded Hair Cycle Induction and Inhibition of Adipocyte Growth in EgfrWa5 Mice Journal of Dermatological Science · 2010
    10. Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes Proceedings of the National Academy of Sciences of the United States of America · 2006
    11. Hair Growth Control by Follistatin Enshou saisei · 2004
    12. Skin-Specific Expression of a Truncated E1a Oncoprotein Binding to p105-Rb Leads to Abnormal Hair Follicle Maturation Without Increased Epidermal Proliferation The Journal of Cell Biology · 1993