Defining the Complex Epithelia That Comprise the Canine Claw With Molecular Markers of Differentiation

October 2009 in “ Veterinary Dermatology ”

Paul E. Bowden, Hayley Henderson, J. D. REILLY

keratin K5 K6 K14 K16 K17 keratinization epithelial structures cellular differentiation

TLDR Canine claws have complex structures with different keratin types, similar to hair and nails.

The study investigated the complex epithelial structures of canine claws, which resemble mammalian hair fibers and human nail plates. Researchers examined keratin expression in the claws of German shepherd dogs, identifying distinct regions and cell lineages undergoing hard or soft keratinization. The claw plate expressed hair-specific keratins, while the soft keratinizing sole epithelium expressed different keratins, including K5, K6, K14, K16, and K17. Two slippage zones were identified, with specific keratin expressions, indicating a complex mechanism of cellular differentiation in canine claws.

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Defining the Complex Epithelia That Comprise the Canine Claw With Molecular Markers of Differentiation

Research cited in this study

research K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), And K28 (K25irs4) Represent The Type I Inner Root Sheath Keratins Of The Human Hair Follicle

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research Keratin K6irs Is Specific to the Inner Root Sheath of Hair Follicles in Mice and Humans

research The Catalog of Human Hair Keratins

research Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and Its Relevance for the Pachyonychia Congenita Phenotype

research Keratin Expression in the Normal Nail Unit: Markers of Regional Differentiation

research The Catalog of Human Hair Keratins

research A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle

research Characterization of a 190-Kilobase Pair Domain of Human Type I Hair Keratin Genes

research Characterization and Chromosomal Localization of Human Hair-Specific Keratin Genes and Comparative Expression During the Hair Growth Cycle

research Mutation of a Type II Keratin Gene (K6a) in Pachyonychia Congenita

research Hair Follicle Companion Layer: Reacquainting an Old Friend

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