Broussonetia Papyrifera Promotes Hair Growth Through the Regulation of β-Catenin and STAT6 Target Proteins: A Phototrichogram Analysis of Clinical Samples

June 2020 in “ Cosmetics ”

Young Han Lee, Gnu Nam, Myong-Ki Kim, Seok-Cheol Cho, Bu Young Choi

Broussonetia papyrifera β-catenin STAT6 human hair follicle dermal papilla cells hair density hair count scalp tonic B. papyrifera hHFDP cells

TLDR Broussonetia papyrifera extract helps hair growth by regulating specific proteins.

The study demonstrated that Broussonetia papyrifera promoted hair growth by regulating β-catenin and STAT6 target proteins. In vitro assays showed significant proliferation of human hair follicle dermal papilla (hHFDP) cells and increased luciferase activity. A clinical trial with 11 participants using a scalp tonic containing B. papyrifera for 12 weeks showed a significant increase in hair density and total hair count. The findings suggested that B. papyrifera could be a promising natural alternative for promoting hair growth.

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