Broussonetia Papyrifera Promotes Hair Growth Through the Regulation of β-Catenin and STAT6 Target Proteins: A Phototrichogram Analysis of Clinical Samples

    June 2020 in “ Cosmetics ”
    Young Han Lee, Gnu Nam, Myong-Ki Kim … Bu Young Choi
    Studysummary This study reports that Broussonetia papyrifera extract significantly increased hair count over 12 weeks in a small clinical trial and promoted dermal papilla cell proliferation in vitro by regulating WNT-β-catenin and STAT6 pathways.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 28

    1. Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia BioMed Research International · 2020
    2. Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the Akt/β-Catenin Signaling Pathway Journal of Microbiology and Biotechnology · 2019
    3. Herbal Preparations for the Treatment of Hair Loss Archives of Dermatological Research · 2019
    4. Ginkgolide B and Bilobalide Promote Growth and Increase β-Catenin Expression in Hair Follicle Dermal Papilla Cells of American Minks BioFactors · 2019
    5. Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia International Journal of Molecular Sciences · 2019
    6. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    7. Flavonoid Silibinin Increases Hair-Inductive Property Via Akt and Wnt/β-Catenin Signaling Activation in 3-Dimensional Spheroid Cultured Human Dermal Papilla Cells Journal of Microbiology and Biotechnology · 2019
    8. JAK Inhibitors for Treatment of Alopecia Areata ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2018
    9. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    10. Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia Archives of Dermatological Research · 2018
    11. A New Classification of Early Female Pattern Hair Loss International Journal of Trichology · 2018
    12. Alginate-Based Hydrogel Containing Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex for Topical Alopecia Treatment Journal of Pharmaceutical Sciences · 2017
    13. Ethnopharmacological Survey of Home Remedies Used for Treatment of Hair and Scalp and Their Methods of Preparation in the West Bank, Palestine BMC complementary and alternative medicine · 2017
    14. 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling Biomolecules & Therapeutics · 2016
    15. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    16. Hair Growth: Focus on Herbal Therapeutic Agents Current Drug Discovery Technologies · 2015
    17. Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia Expert Opinion on Therapeutic Targets · 2014
    18. Calcineurin/NFATc1 Signaling Links Skin Stem Cell Quiescence to Hormonal Signaling During Pregnancy and Lactation Genes & Development · 2014
    19. Age-Associated Inflammation Inhibits Epidermal Stem Cell Function Genes & development · 2012
    20. Effects of a New Mild Shampoo for Preventing Hair Loss in Asians Using a Simple Hand-Held Phototrichogram Technique International Journal of Cosmetic Science · 2011
    21. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    22. Erythropoietin Promotes Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice Journal of Dermatological Science · 2010
    23. A New Classification of Pattern Hair Loss That Is Universal for Men and Women: Basic and Specific (BASP) Classification Journal of The American Academy of Dermatology · 2007
    24. The Hair Cycle Journal of Cell Science · 2006
    25. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    26. Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    27. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    28. Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways Proceedings of the National Academy of Sciences of the United States of America · 2000

    Related research 1

    1. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015