An Induced Pluripotent Stem Cell-Based Approach for Hair Follicle Development and Regeneration

In a double-blind, randomized study with 68 Brazilian men, oral minoxidil was found to be as effective as topical minoxidil 5% in treating androgenetic alopecia, or male pattern baldness.

In this study, gene therapy using a VDR-expressing adenoviral vector promoted hair growth in Vdr-KO rats, suggesting its potential for treating alopecia associated with type II rickets.

This study explored the effects of oxytocin on hair growth and found that it upregulated growth-promoting factors in dermal papilla cells and hair follicle organoids, suggesting potential for developing new alopecia treatments.

This review outlines the potential of using human pluripotent stem cells for hair follicle bioengineering, detailing current HF morphogenesis and cycling knowledge, various cell sources, and strategies using iPSCs, while discussing the challenges and prospects for therapeutic use in addressing hair loss.

This review evaluates the hair cycle's phases and the factors influencing the transition between anagen and telogen, advocating for a holistic approach to addressing hair loss, though no specific results are reported.

This review discusses regenerative medicine approaches for treating alopecia, including mesenchymal stem cell therapies and platelet-rich plasma, but reports no new clinical results, emphasizing the need for further study.

This review discusses the potential of cell-derived nanovesicles as innovative treatment strategies for hair growth and provides no new clinical results; the authors emphasize the need for further understanding of their mechanisms.

This study successfully developed 3D hair follicle organoids from neonatal mouse epidermal and dermal cells, showing structural and molecular resemblance to native anagen hair follicles.

This review explores regenerative treatment options for non-scarring alopecia, with a focus on the potential of mesenchymal stem cells for hair regrowth, but it reports no new clinical results.

This article reviews the potential of using induced pluripotent stem cells for hair restoration, underscoring their promise over current surgical methods, but reports no new clinical results.

In this study, WGBP-A2 polysaccharides from Ginkgo biloba leaves promoted hair growth and altered inflammation markers in alopecia areata mice, suggesting potential therapeutic effects through modulation of inflammation pathways.

This review examines the challenges of hair follicle regeneration and outlines strategies for bioengineering human hair follicle models, without presenting new experimental results.

This review discusses potential cell sources and bioengineering strategies for regenerating hair follicles with functional cycling, reporting no new results.

This review indicates that low-level laser therapy may stimulate hair growth in both men and women with androgenetic alopecia, showing similar efficacy to minoxidil in some studies, but requires more robust evidence.

This review discusses the unique characteristics and disorders of Asian hair, emphasizing the need for more comprehensive studies in this area.

This study found that injecting autologous dermal sheath cup cells significantly increased hair density and diameter in male and female pattern hair loss compared to a placebo for up to 9 months.

This study found that autologous platelet-rich plasma injections showed no significant effect on hair regrowth in patients with alopecia areata totalis.

This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.

In this study, researchers used genetic data from over 52,000 men to identify over 250 genetic loci associated with severe hair loss and developed a predictive algorithm for determining hair loss risk.

This study found that hair follicles can be used to generate pluripotent stem cells, which successfully differentiate into keratinocytes and may improve hair regeneration and grafting for medical applications.

This study found that platelet-rich plasma injections significantly increased hair count and density in patients with male pattern hair loss without major side effects, suggesting it may be a safe and effective treatment option.

This study found that human dermal papilla cells reprogram into induced pluripotent stem cells with higher efficiency than dermal fibroblasts, demonstrating their potential as an alternative source for iPS cells.

This study demonstrated that dermal papilla cells were more efficiently reprogrammed into induced pluripotent stem cells than dermal fibroblasts, suggesting their potential as a source for iPS cells.

This review discusses mesenchymal–epithelial interactions in hair follicle development and cycling, highlighting recent insights without reporting new experimental results.

This review discusses the methodology, limitations, and advantages of Follicular Unit Extraction in hair transplantation without providing new clinical results.