A Disulfide-Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self-Assembly Mechanism to Functional Application in Hair Regeneration
July 2026
in “
Advanced Science
”
disulfide-sticker strategy recombinant scallop adhesive protein Sbp9 Δ dynamic disulfide bonds Ca 2+ coordination β-sheet-rich nanostructures antioxidant properties angiogenesis follicular cell proliferation reactive oxygen species minoxidil androgenetic alopecia hair follicles Wnt signaling pathway calcium signaling pathways marine adhesive mechanisms Rogaine
Studysummary In this study, researchers found that a scallop adhesive protein (Sbp9 Δ) forms strong adhesive coatings via disulfide-sticker strategies, which also promote hair regeneration in mouse models by activating Wnt signaling and enhancing angiogenesis, proving more effective than minoxidil for androgenetic alopecia.
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