The Bis(1,2,3,4-Tetrahydroisoquinoline) Alkaloids Cepharanthine And Berbamine Are Ligands Of SK Channels

    January 2024 in “ ACS Medicinal Chemistry Letters ”
    Romain Vitello, Hossein Taouba, Marine Derand, Jean‐François Liégeois
    Studysummary This study found that the alkaloids cepharanthine and berbamine bind to SK2 and SK3 channel subtypes with affinities that match their concentrations active against various diseases, prompting further investigation into SK channels' role in their therapeutic effects.
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    Research cited in this study 3

    1. Pharmacological Effects and Clinical Prospects of Cepharanthine Molecules · 2022
    2. Cepharanthine: A Review of the Antiviral Potential of a Japanese-Approved Alopecia Drug in COVID-19 Pharmacological Reports · 2020
    3. Cepharanthine: An Update of Its Mode of Action, Pharmacological Properties, and Medical Applications Phytomedicine · 2019