Cepharanthine and berbamine, both alkaloids with structural similarities to known SK channel blockers, were evaluated for their affinity to SK2 and SK3 channels. The study found that cepharanthine has K<sub>i</sub> values of 1,318 μM for SK2 and 1,091 μM for SK3, while berbamine shows stronger affinities with K<sub>i</sub> values of 0,284 μM for SK2 and 0,679 μM for SK3. These affinities align with the concentrations at which these alkaloids are therapeutically active, suggesting a potential role of SK channels in their pharmaceutical effects and warranting further investigation into this interaction.
70 citations
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July 2020 in “Pharmacological Reports” Cepharanthine, a Japanese hair loss drug, shows promise as a COVID-19 treatment but needs more testing.
125 citations
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May 2019 in “Phytomedicine” Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.
81 citations
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June 2010 in “Journal of Dermatological Treatment” The document concludes that minoxidil and finasteride are proven for hair growth, herbal remedies show promise, but more research is needed to confirm their effectiveness.
125 citations
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May 2019 in “Phytomedicine” Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.
29 citations
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November 2021 in “FEBS Open Bio” Cepharanthine analogues, especially tetrandrine, show potential for treating COVID-19.
Cepharanthine and tetrandrine show promise as COVID-19 drugs.
9 citations
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June 2022 in “Microorganisms” We need safe, affordable drugs to fight coronaviruses effectively.
