The Charnoly Body as a Universal Biomarker of Cell Injury
September 2014
in “
Biomarkers and Genomic Medicine
”
TLDR Charnoly bodies could be a marker for cell damage, and certain nutrients and proteins might prevent them, potentially helping with brain diseases and cancer.
The document from 2014 explores the Charnoly body (CB) as a potential universal biomarker for cell injury, with a focus on neurodegenerative diseases like Alzheimer's and Parkinson's, as well as cancer. The study indicates that CBs form in mitochondria under stress and can impair cellular functions. It was found that metallothioneins (MTs) can inhibit CB formation, and nutritional rehabilitation can reverse CB formation. The research involved experiments on undernourished rats, mitochondrial genome knockout cells, and MT gene-manipulated mice. The findings suggest that mitochondrial DNA damage is an early indicator of neurodegenerative diseases, and that MTs, as well as certain drugs and omega-3 fatty acids, could have therapeutic potential in preventing neurodegeneration and depression by inhibiting CB formation. The study involved 12 animals per experimental group for nutritional rehabilitation and 20 normal and 20 undernourished rats for electrophysiological studies.
