Hair-Follicle-Associated Pluripotent Stem Cell Sheet Implantation Accelerates Wound Closure and Suppresses Scar Formation in a Mouse Model

    February 2025 in “ Cell Cycle ”
    Koya Obara, Kyoko Baba, Kyoumi Shirai … Robert M. Hoffman
    Studysummary This study found that implanting hair-follicle-associated pluripotent stem cell sheets in mice significantly accelerated wound closure and reduced scar formation compared to non-implanted controls.
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    Research cited in this study 11

    1. Hair-Follicle Associated Pluripotent Cell-Sheet Implantation Enhanced Wound Healing in Diabetic db/db Mice PLoS ONE · 2024
    2. Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration Mediators of Inflammation · 2017
    3. Isoproterenol Directs Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Differentiate In Vitro to Cardiac Muscle Cells Which Can Be Induced to Form Beating Heart-Muscle Tissue Sheets Cell cycle/Cell cycle (Georgetown, Tex. Online) · 2016
    4. From Hair to Heart: Nestin-Expressing Hair-Follicle-Associated Pluripotent Stem Cells Differentiate to Beating Cardiac Muscle Cells Cell Cycle · 2015
    5. Advances in Skin Grafting and Treatment of Cutaneous Wounds Science · 2014
    6. Nerve Dependence in Tissue, Organ, and Appendage Regeneration Trends in Neurosciences · 2012
    7. Multipotent Nestin-Expressing Stem Cells Capable of Forming Neurons Are Located in the Upper, Middle, and Lower Part of the Vibrissa Hair Follicle Cell Cycle · 2012
    8. Implanted Hair Follicle Stem Cells Form Schwann Cells That Support Repair of Severed Peripheral Nerves Proceedings of the National Academy of Sciences · 2005
    9. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005
    10. Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells Proceedings of the National Academy of Sciences · 2004
    11. Nestin Expression in Hair Follicle Sheath Progenitor Cells Proceedings of the National Academy of Sciences · 2003