Cold Atmospheric Microwave Plasma Stimulates Dermal Papilla Cell Proliferation by Inducing Beta-Catenin Signaling

February 2023 in “ Scientific Reports ”

Kuljira Mongkolpobsin, Chanin Sillapachaiyaporn, Pattawika Lertpatipanpong, Kanokkan Boonruang, Cheol-Yong Hwang, Tewin Tencomnao, Seung Joon Baek

Cold Atmospheric Microwave Plasma CAMP dermal papilla cells β-catenin signaling YAP/TAZ USP47 INPP5D mRNA Akt phosphorylation GSK-3β phosphorylation HaCaT keratinocytes hair follicle induction β-catenin INPP5D Akt GSK-3β HaCaT

Studysummary This study suggests that cold atmospheric microwave plasma treatment may promote hair renewal by activating β-catenin and YAP/TAZ signaling in human dermal papilla cells.

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research Effects of the PI3K/Akt Signaling Pathway on the Hair Inductivity of Human Dermal Papilla Cells in Hair Beads

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research Non-Thermal Atmospheric Pressure Plasma Activates Wnt/β-Catenin Signaling in Dermal Papilla Cells

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This study found that non-thermal atmospheric pressure plasma may stimulate hair growth through activation of the Wnt/β-catenin signaling pathway, suggesting it could be a potential non-pharmacological treatment for alopecia.

research Liposomal Honokiol Promotes Hair Growth Via Activating Wnt3a/β-Catenin Signaling Pathway and Downregulating TGF-β1 in C57BL/6N Mice

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research Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride

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research Tolerability of Six Months Indirect Cold Physical Plasma Treatment of the Scalp for Hair Loss

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This study found that indirect treatment with cold atmospheric plasma showed promise for improving androgenetic alopecia in patients, laying the groundwork for longer trials to assess its efficacy.

research Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling

65 citations , July 2020 in “Science Advances”

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research Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the Akt/β-Catenin Signaling Pathway

37 citations , November 2019 in “Journal of Microbiology and Biotechnology”

This study found that loliolide enhanced hair growth-related functions in 3D dermal papilla spheroids by activating AKT/β-catenin signaling pathways, with increased expression of related growth factors and genes.

research Keratinocytes Maintain Compartmentalization Between Dermal Papilla and Fibroblasts in 3D Heterotypic Tri-Cultures

16 citations , August 2019 in “Cell Proliferation”

This study found that 3D cultured hair follicle-like constructs, which include keratinocytes and dermal papilla cells, showed improved gene expression and cell interactions relevant to hair follicle development.

research Beta-Catenin-Mediated Hair Growth Induction Effect of 3,4,5-Tri-O-Caffeoylquinic Acid

42 citations , June 2019 in “Aging”

This study found that treatment with the polyphenolic compound TCQA activated β-catenin, promoting hair regrowth and the initiation of the anagen phase in mice and human dermal papilla cells.

research Integrin Signaling Regulates YAP/TAZ to Control Skin Homeostasis

266 citations , January 2016 in “Development”

In this study, researchers found that YAP and TAZ, when localized in the nucleus of basal layer cells, are crucial for skin regeneration and hair growth, with their loss leading to slower cell proliferation, hair loss, and impaired wound healing in mice.

Lipid Nanoparticles for Topical and Transdermal Application for Alopecia Treatment: Development, Physicochemical Characterization, and In Vitro Release and Penetration Studies

research Lipid Nanoparticles for Topical and Transdermal Application for Alopecia Treatment: Development, Physicochemical Characterization, and In Vitro Release and Penetration Studies

28 citations , March 2014 in “International Journal of Nanomedicine”

This study developed lipid nanoparticles for delivering minoxidil and finasteride to the dermis and hair follicles, showing stability and a desired prolonged release, though with low skin penetration levels.

Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

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This study found that androgenetic alopecia may involve a defect in the conversion of hair follicle stem cells to progenitor cells, as demonstrated by a reduced presence of progenitor cells in bald scalp samples.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

This study found that in mice, inactivating beta-catenin in the dermal papilla reduces hair follicle progenitor proliferation and disrupts the hair cycle.

The Enhancement of Dermal Papilla Cell Aggregation by Extracellular Matrix Proteins Through Effects on Cell–Substratum Adhesivity and Cell Motility

research The Enhancement of Dermal Papilla Cell Aggregation by Extracellular Matrix Proteins Through Effects on Cell–Substratum Adhesivity and Cell Motility

44 citations , June 2009 in “Biomaterials”

In this study, fibronectin coating on a low-adhesive substratum increased cell aggregation, growth, and motility, enhancing the formation of hair follicle dermal papilla spheroids.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

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research Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors

335 citations , March 2004 in “Development”

This study found that continuous β-catenin signaling in adult mouse epidermis can reprogram hair follicles to form benign tumors, which regress after the signaling is discontinued.

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277 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

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