Bioinspired Strategies for Wound Regeneration

    December 2022 in “ Cold Spring Harbor Perspectives in Biology ”
    Hans I‐Chen Harn, Jeffrey M. Davidson, Cheng‐Ming Chuong
    Studysummary This review examines diverse regenerative strategies in animals and highlights how biochemical, immunological, and mechanical signals can work together for successful skin regeneration in adult mammals, but it reports no new experimental results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 22

    1. MSC-Derived sEV-Loaded Hyaluronan Hydrogel Promotes Scarless Skin Healing by Immunomodulation in a Large Skin Wound Model Biomedical Materials · 2022
    2. Fibroblasts: Origins, Definitions, and Functions in Health and Disease Cell · 2021
    3. Mechanical and Immunological Regulation in Wound Healing and Skin Reconstruction International Journal of Molecular Sciences · 2021
    4. Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice Nature Communications · 2021
    5. Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging Frontiers in Cell and Developmental Biology · 2021
    6. Wound-Induced Hair Neogenesis: A Novel Paradigm for Studying Regeneration and Aging Frontiers in Cell and Developmental Biology · 2020
    7. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing Cell stem cell · 2020
    8. Noncoding dsRNA Induces Retinoic Acid Synthesis to Stimulate Hair Follicle Regeneration via TLR3 Nature Communications · 2019
    9. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019
    10. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    11. Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1-Dependent Manner Journal of Investigative Dermatology · 2018
    12. Mechanical Forces in Skin Disorders Journal of Dermatological Science · 2018
    13. Scarless Wound Healing: Transitioning from Fetal Research to Regenerative Healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018
    14. The Blastema and Epimorphic Regeneration in Mammals Developmental Biology · 2017
    15. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    16. Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing Development · 2016
    17. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    18. Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations Cell · 2015
    19. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    20. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012
    21. New Hair From Healing Wounds Nature · 2007
    22. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007