Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?

    June 2022 in “ Frontiers in Immunology ”
    Li Yu, Huiqian Yu, Shuai Zhang … Shoumin Zhang
    Studysummary This report describes a case of alopecia universalis successfully treated with tofacitinib, though it was associated with increased peripheral blood cytokine levels.
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    Research cited in this study 10

    1. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    2. Evaluation of the Level of Serum Interleukins (IL-2, IL-4, IL-15, and IL-17) and Its Relationship with Disease Severity in Patients with Alopecia Areata Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2021
    3. Alopecia Areata: An Autoimmune Disease of Multiple Players ImmunoTargets and therapy · 2021
    4. A Comprehensive Literature Review of JAK Inhibitors in the Treatment of Alopecia Areata Clinical, cosmetic and investigational dermatology · 2021
    5. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    6. The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials British Journal of Dermatology · 2020
    7. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    8. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    9. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    10. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014

    Related research 10

    1. Efficacy of Janus Kinase Inhibitors in Adult Patients With Alopecia Areata International journal of research in dermatology · 2023
    2. Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal? Frontiers in Immunology · 2022
    3. A Case of Atopic Dermatitis with Alopecia Universalis in a Patient Treated with Abrocitinib JAAD case reports · 2022
    4. Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis Journal of Cosmetic Dermatology · 2020
    5. The Use of Janus Kinase Inhibitors in Alopecia Areata: A Review of the Literature Journal of cutaneous medicine and surgery · 2019
    6. Role of Janus Kinase Inhibitors in the Treatment of Alopecia Areata Drug design, development and therapy · 2018
    7. Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib PubMed · 2018
    8. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    9. Reversal of Alopecia Universalis by Tofacitinib: A Case Report Annals of Internal Medicine · 2016
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