Efficacy of Janus Kinase Inhibitors in Adult Patients With Alopecia Areata

    August 2023 in “ International journal of research in dermatology ”
    Andrea Sierra Franco, Paulina García de León Flores, Paula Alba, María Jimena Talamante Madrid, C. E. Calvo Rodríguez, Renata Monserrat Espejo Nuño
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    TLDR Janus kinase inhibitors are effective and generally safe for treating hair loss in adults with alopecia areata.
    The study reviewed literature from January 1, 2017, to April 16, 2023, on the efficacy and safety of Janus kinase inhibitors (JAKis) in treating adult patients with alopecia areata (AA). The findings indicate that oral JAKis, including tofacitinib, ruxolitinib, and baricitinib, are effective in reducing hair loss and are generally safe for use, even in severe cases of AA. The authors suggest that further research is needed to optimize dosage and treatment duration.
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      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

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