September 202449
Robotic harvesting versus manual FUE showed slightly higher graft discard rates with similar transection and satisfaction. Oral minoxidil with spironolactone or finasteride gave similar hair growth gains in women with comparable safety. Dutasteride for androgenetic alopecia was more effective than finasteride with mostly mild, reversible adverse events, though sexual and possible psychiatric risks remain. Minoxidil as first-line therapy was recommended for pattern hair loss, with oral finasteride an option for men. Cold gel compresses during microneedling were recommended as monotherapy over lidocaine cream or spray. GLP-1 agonists and hair loss reporting showed the most reports among drug classes but no formal safety signal, with authors urging continued monitoring rather than concluding safety.
- A Comparative Study on the Application of Robotic Hair Restoration Technology Versus Traditional Follicular Unit Excision in Male Androgenetic Alopecia In a 13-patient split-scalp comparison, robotic ARTAS harvesting had slightly higher graft discard rates than manual FUE but similar transection, satisfaction, and safety.
- Comparative analysis of low-dose oral minoxidil with spironolactone versus finasteride or dutasteride in female androgenetic alopecia management In women with pattern hair loss, oral minoxidil combined with either spironolactone or finasteride/dutasteride gave similar hair growth gains and comparable safety.
- Dutasteride for the Treatment of Androgenetic Alopecia: An Updated Review A review finds oral dutasteride more effective than finasteride with mostly mild, reversible adverse events, though sexual and possible psychiatric risks remain; topical and injectable forms need more trials.
- Risk of Suicide, Hair Loss, and Aspiration with GLP1-Receptor Agonists and Other Diabetic Agents: A Real-World Pharmacovigilance Study Across four pharmacovigilance databases, GLP-1 agonists were the most-reported drug class for hair loss but no formal safety signal was detected; authors urge continued monitoring rather than concluding the drugs are safe.
- Hair Loss: Diagnosis and Treatment. A review of hair loss diagnosis and treatment: minoxidil is first-line for androgenetic alopecia, with oral finasteride an option for men.
- Efficacy and safety of ritlecitinib, an oral JAK3/TEC family kinase inhibitor, in adolescent and adult patients with alopecia totalis and alopecia universalis In ALLEGRO, ritlecitinib gave week-48 SALT ≤20 responses of 13%-31% in alopecia totalis/universalis patients versus 0% on placebo at week 24, with acceptable safety.
- The efficacy of light-guiding microneedle patch for stimulating hair growth in androgenetic alopecia In a 16-patient randomized trial, a light-guiding microneedle patch with red or green LED light significantly increased hair density and diameter over 24 weeks.
- Chemotherapy-Induced Alopecia by Docetaxel: Prevalence, Treatment and Prevention A review of docetaxel-induced hair loss: scalp cooling is the standard prevention, while minoxidil, photobiomodulation, and PRP can aid regrowth.
- Facile fabrication of cedrol nanoemulsions with deep transdermal delivery ability and high safety for effective androgenic alopecia treatment Cedrol nanoemulsions inhibited 5-alpha-reductase, lowered skin DHT, and regenerated hair follicles in AGA-model mice.
- Therapeutic Effect of Superficial Scalp Hypothermia on Chemotherapy-Induced Alopecia in Breast Cancer Survivors A review finds scalp cooling halves the incidence of chemotherapy-induced alopecia with high satisfaction and no increase in scalp metastasis or survival compromise.
- Improvement of androgenic alopecia by extracellular vesicles secreted from hyaluronic acid-stimulated induced mesenchymal stem cells In mice, extracellular vesicles from hyaluronic acid-primed stem cells restored hair growth comparable to finasteride by reactivating Wnt/beta-catenin signaling.
- Real‐life effectiveness and safety of baricitinib in patients with severe alopecia areata: A 24‐week Italian study In a 118-patient Italian real-world study, baricitinib cut average SALT scores from 97 to 48 by week 24, with mild lab abnormalities in 12.7%.
- Evaluating the efficacy of local anesthetic techniques during scalp microneedling In 62 men undergoing scalp microneedling, comparing lidocaine-prilocaine cream, lidocaine spray and cold gel compresses, cold gel compresses were recommended as monotherapy.
- Terminalia bellirica (Gaertn.) Roxb. extracts reshape the perifollicular microenvironment and regulate the MAPK pathway for androgenetic alopecia treatment In mice, Terminalia bellirica extract regrew hair comparably to minoxidil by inhibiting type II 5-alpha-reductase and activating the MAPK pathway.
- Development of a Standardized Photo Guideline for Online Hair Transplantation Consultation A survey of 570 patients found high satisfaction with online hair transplant consultations, and a standardized photo guideline improved submitted image quality.
- Trichoscopy and LC-OCT findings in sonidegib-induced alopecia in patients with advanced basal cell carcinoma In 45 basal cell carcinoma patients on sonidegib, 11 developed alopecia; trichoscopy and LC-OCT characterized its features, with LC-OCT possibly aiding early detection.
- A Novel Cosmetic Formulation That Rapidly Reduces Hair Shedding in Females a novel cosmetic formulation is claimed to rapidly reduce hair shedding in females.
- In Vivo Imaging Techniques for the Human Scalp: A Systematic Review of the Literature A systematic review of 42 studies found noninvasive scalp imaging (confocal microscopy, OCT, ultrasound) promising for evaluating hair loss without biopsy.
- The association between alcohol consumption and the severity of male Androgenic Alopecia in Chinese participants: A Single-Center Cross-Sectional Study a cross-sectional study examining the association between alcohol consumption and male pattern hair loss severity in Chinese participants.
- A pig model exploring the postnatal hair follicle cycle In pigs, the first hair follicle cycle was classified (anagen to P45, catagen P45–P85, telogen P85–P100), supporting pigs as a human hair research model.
- Ginger-Derived Extracellular Vesicles: A Natural Solution for Alopecia Ginger-derived extracellular vesicles promoted hair regrowth in a mouse alopecia model by reducing inflammation and stimulating follicle stem cells.
- An Assessment of the Safety, Efficacy, and Tolerability of a Novel Scalp Treatment Regimen Combining a Hydroxy Acid-Based Scrub and Copper Tripeptide Serum in the Management of Seborrheic Dermatitis in Adults An open-label study of a hydroxy-acid scrub plus copper tripeptide serum for dandruff found reduced flaking and improved hydration over 15 days.
- Combination Therapy With CGF and Microneedling‐Assisted Compound Betamethasone for Resistant Alopecia Areata: APilot Study In a seven-patient pilot, concentrated growth factor plus microneedling-assisted betamethasone produced significant regrowth in resistant alopecia areata, with six achieving complete recovery.
- Dermal white adipose tissue: Development and impact on hair follicles, skin defense, and fibrosis A review of dermal white adipose tissue describing its roles in hair cycle regulation, skin defense, and anti-fibrotic functions.
- Chronic circadian misalignment is a risk factor for hair growth impairment In mice, chronic circadian misalignment from repeated light-dark reversal slowed anagen hair growth, suggesting disrupted light cycles as a hair loss risk factor.
- Association study reveals a susceptibility locus with male pattern baldness in the Han Chinese population A Han Chinese study confirmed the rs13405699 gene variant at 2q31.1 is associated with male pattern baldness risk.
- The overexpression of R-spondin 3 affects hair morphogenesis and hair development along with the formation and maturation of the hair follicle stem cells In mice, R-spondin 3 overexpression caused sparse hair, shortened growth phase, and impaired hair follicle stem cell maturation.
- ARHGEF3 Regulates Hair Follicle Morphogenesis In mouse embryos, ARHGEF3 controls cadherin patterning in early hair follicle formation; its loss enlarges placodes and disrupts follicle downgrowth.
- Periauricular hair transplantation enhances the cosmetic results of eyebrow transplantation: A retrospective study in Chinese recipients In 81 Chinese patients, eyebrow transplantation using periauricular hair gave high 15-month satisfaction (mean 4.90/5) with no significant complications.
- Hair regrowth in alopecia areata and re‐pigmentation in vitiligo in response to treatment: Commonalities and differences A review comparing hair regrowth in alopecia areata with repigmentation in vitiligo, explaining faster JAK inhibitor response in AA via stem cell biology.
- Total glucosides of paeony inhibit NLRP3/caspase-1/GSDMD-mediated inflammation and pyroptosis in C3H/HeJ mice with alopecia areata In AA mice, total glucosides of paeony reduced hair loss and inflammation by inhibiting NLRP3/caspase-1/GSDMD-mediated pyroptosis.
- Impact of Previous Alopecia Areata Treatment on Efficacy Responses up to Week 48 Following Ritlecitinib Treatment: A Post Hoc Analysis In an ALLEGRO post hoc analysis, prior alopecia areata treatments did not affect ritlecitinib response rates by week 48.
- Unraveling Ritlecitinib: an in-depth analysis of JAK3 inhibitor for the treatment of alopecia areata A review of newly approved ritlecitinib for alopecia areata found promising efficacy and favorable safety, while noting long-term safety and real-world data are still needed.
- Fractionated CO2 Laser in Combination with Topical Tacrolimus for Chronic Alopecia Areata: A Case Series Study Three corticosteroid-resistant alopecia areata patients improved with fractional CO2 laser plus topical tacrolimus over 16 weeks; confirmation studies needed.
- Conductive Bio-Harvesting Tonic (CBT) with an Anti-Dandruff Effect Enhances Hair Growth by Utilizing Naturally Generated Electric Energy during Human Activities In mice and cultured human follicles, a tonic with body-motion-generated electric stimulation increased hair shaft length and delayed follicle regression.
- Comparative investigation of immune-related biomarkers related to alopecia areata subtypes Reanalysis of expression data found CXCL9 and CXCL10 as key nodes and potential prognostic factors in alopecia areata subtypes.
- Identification of a Novel Three-immunogene Diagnostic Signature for Alopecia Areata A three-gene immune signature (CD8A, CSF1R, CXCL10) diagnosed alopecia areata with AUC ~0.96 in bioinformatics cohorts.
- Efficacy and safety of compound glycyrrhizin combined with topical minoxidil for alopecia areata: a systematic review and meta-analysis of randomized controlled trials A meta-analysis of 11 RCTs found compound glycyrrhizin plus topical minoxidil beat minoxidil alone in alopecia areata, with no significant difference in adverse events; study quality was suboptimal.
- Low-Dose Metformin and Profibrotic Signature in Central Centrifugal Cicatricial Alopecia In a 12-patient case series, low-dose metformin improved symptoms and reversed fibrotic gene pathways in treatment-resistant scarring alopecia (CCCA).
- Predictors and Management of Inadequate Response to JAK Inhibitors in Alopecia Areata A review found longer episode duration and higher baseline severity predict poor JAK-inhibitor response in alopecia areata, and suggests dose increases, combinations, or switching.
- Health‐related quality of life and well‐being in pediatric patients with alopecia areata and their caregivers A survey of 72 children with alopecia areata found quality-of-life impact comparable to atopic dermatitis, with over 90% of caregivers reporting sadness or anxiety.
- Tolerance and safety profile of sublingual minoxidil in the treatment of androgenic alopecia a study of the tolerance and safety profile of sublingual minoxidil for androgenetic alopecia.
- [Artículo traducido] Características clínicas y sociodemográficas de la alopecia areata en 5 ciudades colombianas: un análisis del RENAAC A Colombian registry of 562 alopecia areata patients found patchy AA predominant and steroid injections the most used treatment.
- Androgenic Alopecia Is Associated With More Severe Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia Men with androgenetic alopecia had worse urinary symptoms from enlarged prostate and higher testosterone than similar men without hair loss.
- Compatibility of Cetirizine Hydrochloride, Dutasteride, Hydrocortisone Acetate, Nicotinamide, Progesterone, and Pyridoxine Hydrochloride in TrichoSolTM, A Natural Vehicle for Hair Solutions. Stability testing gave compounded hair solution ingredients in TrichoSol vehicle beyond-use dates of 90-180 days depending on drug and concentration.
- Is Frontal Fibrosing Alopecia Connected to Sunscreen Usage? a piece asking whether frontal fibrosing alopecia is connected to sunscreen usage.
- ALOPECIA AREATA PROFILING SHOWS LNCRNAS REGULATE THE SUPPRESSED EXPRESSION OF KERATIN. RNA sequencing of scalp from five alopecia areata patients found 344 mRNAs and 116 lncRNAs differentially expressed, with keratin family genes potentially key to pathogenesis.
- Hair-raising costs: Evaluating botulinum toxin treatment for androgenetic alopecia
- Mesotherapy with bicalutamide for female pattern hair loss