July 202472
Low follicle sulfotransferase activity was found to predict response to low-dose oral minoxidil in pattern hair loss. Platelet-rich plasma increased hair density by about 28 hairs/cm² in a meta-analysis, though evidence quality was low. Hair follicle-derived microtissue sped donor-site wound closure and lowered pain after FUE transplantation. Peripheral blood cell injections alone or with finasteride increased hair counts in men with AGA. A Korean GWAS identified three novel loci linked to pattern hair loss. Fractional laser treatment appeared effective for AGA in a review of 15 years of studies.
- Prospective evaluation of blood pressure, heart rate, and side effects in hypertensive patients using low-dose oral minoxidil for hair loss A prospective tracking of blood pressure, heart rate, and side effects in hypertensive patients taking low-dose oral minoxidil.
- Hair follicle sulfotransferase activity and effectiveness of oral minoxidil in androgenetic alopecia In 41 pattern hair loss patients on low-dose oral minoxidil, low follicle sulfotransferase activity predicted response (85% vs 43%).
- Efficacy of Botulinum Toxin in Male Androgenetic Alopecia: a Triple-Blind, Randomized Clinical Trial A triple-blind randomized clinical trial tested botulinum toxin efficacy in male androgenetic alopecia.
- Impact of finasteride and dutasteride in beard thickness in men with androgenetic alopecia: a 453-patient retrospective trial A 453-patient retrospective trial examined the impact of finasteride and dutasteride on beard thickness in men with androgenetic alopecia.
- Is autologous platelet-rich plasma capable of increasing hair density in patients with androgenic alopecia? A systematic review and meta-analysis of randomized clinical trials Meta-analysis of randomized trials: PRP increased hair density by about 28 hairs/cm² in AGA, but evidence was low quality with publication bias.
- A randomized controlled trial on hair follicular-derived microtissue for promoting wound healing and alleviating postoperative complications after hair transplantation In a 98-patient split-scalp trial, hair follicle-derived microtissue sped donor-site wound closure and lowered pain and itching after FUE hair transplantation.
- Assessing the influence of medications with antagonistic effects on low-dose oral minoxidil in patients with alopecia: A retrospective study A retrospective study asking whether medications with opposing effects blunt low-dose oral minoxidil in alopecia patients.
- Incidence of alopecia in brain tumour patients treated with pencil scanning proton therapy and validation of existing NTCP models Among 264 brain tumour patients treated with proton therapy, acute radiation alopecia occurred in 61.8% and permanent alopecia in 14.4%; existing risk models discriminated well but calibrated poorly.
- ICP5249 Promotes Hair Growth by Activating the AMPK-Autophagy Signaling Pathway New autophagy activator ICP5249 promoted hair growth in human dermal papilla cells, human follicles, and mice via AMPK-autophagy signaling.
- Genetic Differences between Male and Female Pattern Hair Loss in a Korean Population A Korean GWAS of about 1000 people found three novel gene loci linked to pattern hair loss, two appearing female-specific.
- Comparative efficacy and safety of systemic steroids, oral JAK inhibitors and Contact Immunotherapy in the Treatment of severe alopecia areata: a systematic review and network meta-analysis A network meta-analysis ranked oral dexamethasone most effective for severe alopecia areata, but ritlecitinib had the best safety among active treatments.
- Efficacy and safety of deuruxolitinib, an oral selective Janus kinase inhibitor, in adults with alopecia areata: Results from the Phase 3 randomized, controlled trial (THRIVE-AA1) In a phase 3 trial, deuruxolitinib gave 30–42% of alopecia areata patients substantial regrowth at 24 weeks versus under 1% on placebo.
- Progress of clinical research on fractional laser treatment of androgenetic alopecia: A review article A review of 15 years of studies: fractional laser treatment for AGA appeared effective and safe, but larger trials are still needed.
- Mechanism and clinical efficacy of peripheral blood alive cell treatment on androgenic alopecia In 60 men with AGA, peripheral blood cell injections alone or combined with finasteride significantly increased hair counts over six months.
- Engineered Exosomes Biopotentiated Hydrogel Promote Hair Follicle Growth via Reprogramming the Perifollicular Microenvironment In AGA mice, an exosome-laden hydrogel delivering minoxidil regrew hair faster than free minoxidil without significant skin irritation.
- Effects of Camellia oleifera seed shell polyphenols and 1,3,6-tri-O-galloylglucose on androgenic alopecia via inhibiting 5a-reductase and regulating Wnt/β-catenin pathway In DHT-induced AGA mice, camellia seed-shell polyphenols and the compound TGG lowered DHT, inhibited 5α-reductase, and improved hair growth.
- Comparison of efficacy and safety of tofacitinib and azathioprine in patients with alopecia areata and variants: a double-blind, randomized controlled trial In a 104-patient trial, tofacitinib clearly beat azathioprine for severe alopecia areata, with far greater regrowth and similar tolerability.
- Nanostructured lipid carriers promote percutaneous absorption and hair follicle targeting of tofacitinib for treating alopecia areata Tofacitinib-loaded lipid nanoparticles targeted hair follicles and reversed hair loss in a mouse alopecia areata model.
- Microsponges-mediated targeted topical delivery of rosemary oil for hair growth promotion: optimization and in-vivo studies Rosemary-oil microsponge gel increased follicular retention three-fold and outgrew minoxidil by about 1.5-fold on hair length and thickness in vivo.
- High‐frequency ultrasonography of the scalp: A comparison between androgenetic alopecia and healthy volunteers 22 MHz ultrasound showed thinner scalps and smaller, fewer follicles in pattern hair loss patients than healthy volunteers.
- Evaluation of Serum Inflammatory Markers and Their Relationship to Treatment Response in Alopecia Areata Patients In 60 alopecia areata patients, the systemic immune-inflammation index tracked disease severity and fell with treatment response.
- 18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase 18-β-Glycyrrhetinic acid stimulated human follicle cell proliferation and inhibited 5α-reductase in vitro, suggesting AGA potential.
- Hydrophilic melanin as a potential hair growth stimulant: A secondary observational study In rats, topical bacterial melanin stimulated hair growth by prolonging anagen and enhancing vasodilation.
- Allergic contact dermatitis of the scalp: a review of an underdiagnosed entity A review finds scalp allergic contact dermatitis is often misdiagnosed as seborrheic dermatitis, and personalized patch testing catches far more cases than standard panels.
- Risk Factors for the Development of and Outcomes After Diagnosis of Autoimmune Alopecia Areata in Patients with Inflammatory Bowel Diseases IBD patients who developed alopecia areata were more often on anti-TNF drugs; most improved regardless of continuing IBD therapy.
- Effects of Nannochloropsis salina Fermented Oil on Proliferation of Human Dermal Papilla Cells and Hair Growth Nigella sativa oil promoted dermal papilla cell proliferation and may reduce oxidative stress in lab models.
- Oral dutasteride is a first‐line treatment for frontal fibrosing alopecia Oral dutasteride is presented as a first-line treatment for frontal fibrosing alopecia, which currently lacks randomized controlled trial evidence.
- Men’s baldness stigma: A mixed methods international survey In a 357-man international survey, about half internalized baldness stigma, with 39-45% reporting distress and 57% pursuing treatments.
- Biologics and Small Molecule Targeted Therapies for Pediatric Alopecia Areata, Psoriasis, Atopic Dermatitis, and Hidradenitis Suppurativa in the US: A Narrative Review A review lists FDA-approved biologics and JAK inhibitors for pediatric alopecia areata, psoriasis, atopic dermatitis and hidradenitis, with more drugs in trials.
- Stimulation of mouse hair regrowth by exosomes derived from human umbilical cord mesenchymal stem cells In mice, human umbilical cord stem cell exosomes sped hair regrowth by activating follicle stem cells and Wnt/β-catenin signaling.
- Dynamic duo: Cell–extracellular matrix interactions in hair follicle development and regeneration A review describes how cell-extracellular matrix adhesion units guide hair follicle development and regeneration.
- The value of immunohistochemical expression of SOX9 and CD34 in alopecia areata Alopecia areata lesions showed reduced SOX9 and CD34 stem cell markers, falling further with greater severity and recurrence, in 20 patients.
- Unique Presentations of Female Pattern Hair Loss Evident in Asian and Black Women In 112 women, female pattern hair loss showed distinct distribution patterns in Asian and Black women, possibly affecting treatment response.
- Dupilumab induces hair regrowth in pediatric alopecia areata: a real-world, single-center observational study In 20 children with atopic dermatitis and alopecia areata, dupilumab steadily reduced hair-loss severity over 48–72 weeks with no new safety concerns.
- Treatment patterns and healthcare resource utilization among patients with alopecia areata: A real‐world chart review in South Korea A South Korean chart review of 151 severe alopecia areata patients found 71% regrew hair, median 13.7 months, with high treatment burden.
- Optimized Depilation Method and Comparative Analysis of Hair Growth Cycle in Mouse Strains An optimized cold-wax depilation method minimized skin injury for synchronizing hair cycles across three mouse strains.
- Subclinical Atherosclerosis in Alopecia Areata: Usefulness of Arterial Ultrasound for Disease Diagnosis and Analysis of Its Relationship with Cardiometabolic Parameters In a case-control study, severe alopecia areata patients had more carotid artery plaque than matched healthy controls (55% vs 23%).
- Enhancing hair regeneration: Recent progress in tailoring nano-structured lipid carriers through surface modification strategies A review discusses surface-modified nanostructured lipid carriers to improve delivery of agents like minoxidil and finasteride for hair loss.
- Exosomes derived from mouse vibrissa dermal papilla cells promote hair follicle regeneration during wound healing by activating Wnt/β-catenin signaling pathway In mice, dermal papilla cell exosomes reprogrammed fibroblasts to form new hair follicles during wound healing via Wnt/β-catenin signaling.
- Effects of RF Electric Currents on Hair Follicle Growth and Differentiation: A Possible Treatment for Alopecia Capacitive resistive electrical transfer increased proliferation and reduced death in follicles from androgenic alopecia patients ex vivo.
- Effects of Biomaterials Derived from Germinated Hemp Seeds on Stressed Hair Stem Cells and Immune Cells Germinated hemp seed biomaterials may reduce hair loss and improve growth in stressed hair stem cell models.
- Development and validation of a patient‐reported outcome measure for hair loss treatment: The HAIR‐Q The 14-item HAIR-Q questionnaire was validated as a reliable measure of patient satisfaction with hair across hair loss conditions.
- The causal relationship between gut microbiota and alopecia areata: a Mendelian randomization analysis A Mendelian randomization analysis suggests a causal relationship between certain gut microbial taxa and alopecia areata.
- Revitalizing skin, hair, nails, and muscles: Unlocking beauty and wellness with vegan collagen A clinical study reports a vegan collagen builder safely improved hair growth and other outcomes over 60 days.
- Therapeutic effect of <i>Nepenthes kampotiana</i> Lecomte ethanol extract (Nk-EE) on androgenic alopecia through the inhibition of apoptosis and 5α-reductase activity Lab and animal work: pitcher plant extract stimulated dermal papilla cells, inhibited 5α-reductase, and improved hair growth markers.
- Delivery Strategies of siRNA Therapeutics for Hair Loss Therapy A review proposes clinically tunable siRNA delivery systems and analyzes trials for hair loss therapy.
- Lichen Planopilaris Trichoscopy in Caucasian Scalp: A Review A review outlines trichoscopic signs of lichen planopilaris to enable earlier diagnosis before permanent scarring.
- Small Molecule Agents Against Alopecia: Potential Targets and Related Pathways A review outlines FDA-approved drugs and emerging small-molecule compounds and pathways for alopecia treatment.
- Response to Mounessa et al.’s “Commonly prescribed medications associated with alopecia’’ A correspondence notes oral retinoids such as isotretinoin and acitretin can cause significant hair loss.
- Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways In AGA mice, pilose antler extract regrew hair by activating follicle stem cells through AKT and Wnt pathways.
- Hair Growth Promoting Effects of 15-Hydroxyprostaglandin Dehydrogenase Inhibitor in Human Follicle Dermal Papilla Cells A 15-PGDH inhibitor reduced oxidative stress and increased hair growth in DHT-damaged human follicle cultures.
- Psychometric Properties of the EQ-5D-5L in Patients with Alopecia Areata In 612 alopecia areata trial patients, the standard EQ-5D-5L questionnaire missed quality-of-life differences that disease-specific measures captured.
- Impact of epidermal growth factor receptor and mitogen-activated kinase inhibition on hair follicles (HFs): partial HF immune privilege collapse and excessive interleukin-33 secretion EGFR and MAPK inhibition partially collapsed hair follicle immune privilege and triggered excess interleukin-33 secretion.
- A phase 2a study investigating the effects of ritlecitinib on brainstem auditory evoked potentials and intraepidermal nerve fiber histology in adults with alopecia areata A 9-month safety study in 71 alopecia areata patients found no auditory or nerve-fiber changes with ritlecitinib, suggesting dog toxicology findings aren't clinically relevant in humans.
- Alopecia areata following COVID-19 vaccine: a systematic review A systematic review of 51 cases found alopecia areata after COVID-19 vaccination is rare, mostly new-onset, appearing within a month of the first dose.
- Dupilumab for the treatment of alopecia areata in pediatric patients with atopic dermatitis: A scoping review A scoping review found dupilumab cut hair-loss severity scores by a mean of 42.6 points in children with alopecia areata and atopic dermatitis.
- Network Pharmacology Reveals Curcuma aeruginosa Roxb. Regulates MAPK and HIF-1 Pathways to Treat Androgenetic Alopecia Computer modeling predicted Curcuma aeruginosa compounds may counter AGA via MAPK and HIF-1 pathways; no lab testing was performed.
- A New Method for the Follow-Up of Patients with Alopecia Areata Tele-trichoscopy follow-up for alopecia areata matched in-person image quality and patient satisfaction over one year.
- The correlation between corona virus disease 2019 and alopecia areata: a literature review A review finds COVID-19 raises autoimmune disease risk and examines how infection or vaccination may trigger alopecia areata.
- Association between PITX2 polymorphism and androgenetic alopecia in the Indian population In 70 Indian men with AGA versus 60 controls, certain PITX2 gene variants were associated with up to sixfold higher AGA risk.
- Association Between Natural Hair Color, Race, and Alopecia Black hair color was associated with higher alopecia areata risk, while red or blonde hair was associated with lower risk.
- Sonographic comparison of subcutaneous fat layer thickness in the scalp area in patients with androgenetic alopecia compared to healthy individuals: Cross‐sectional Scalp subcutaneous fat thickness was compared between androgenetic alopecia patients and healthy individuals using ultrasound.
- The Roles of Exosomes in Regulating Hair Follicle Growth A review: animal and cell studies show exosomes from dermal papilla and mesenchymal stem cells can promote hair growth.
- Exploring the Relationship Between Immune Cells and Non-Scarring Hair Loss: A Mendelian Randomization Study Mendelian randomization links certain immune cells to non-scarring hair loss, suggesting immune-targeted possibilities.
- AP collagen peptides (APCPs) promote hair growth by activating the GSK‐3β/β‐catenin pathway and improve hair condition AP collagen peptides accelerated hair growth in human and mouse models via GSK-3β/β-catenin signaling.
- Assessing the efficacy of mesotherapy products: Ultra Exo Booster, and Ultra S Line Plus in hair growth: An ex vivo study In cultured human hair follicles, commercial exosome-based mesotherapy products elongated hair and delayed transition to the regression phase.
- Application of Non-Pharmacologic Therapy in Hair Loss Treatment and Hair Regrowth A review summarizes non-pharmacologic therapies that may promote hair growth as alternatives to drugs and transplantation.
- Atopic diseases and the risk of alopecia areata among pre-teens and teenagers in Taiwan Taiwanese teens with atopic diseases had nearly tenfold higher risk of developing alopecia areata than peers without.
- Clinical Profile and Predictors of Relapse in Patients with Alopecia Areata: A Follow-Up Study A follow-up study found 71% of alopecia areata patients relapsed after remission, with early onset and extensive disease as possible predictors.
- Comparative Study of Trichoscopic Features of Alopecia Areata between Adults and Children and between Different Body Parts (Scalp, Beard, Eyebrow, and Moustache) Trichoscopy of 90 patients showed empty follicular openings dominate adult alopecia areata while honeycomb pigment dominates in children.
- Clinicopathological Features of Frontal Fibrosing Alopecia (FFA) in 26 females: A Retrospective Study In 26 women with frontal fibrosing alopecia, absent vellus hairs and fibrous-sheath replacement of follicles were the most common findings.
- Hypoxic Preconditioning Prevents Oxidative Stress-Induced Cell Death in Human Hair Follicle Stem Cells. Hypoxic preconditioning protected human hair follicle stem cells from oxidative stress–induced death in vitro.