May 202443
Adding Er:YAG laser to standard medication improved hair counts and thickness versus medication alone. A network meta-analysis of monotherapies ranked dutasteride 0.5 mg most effective, ahead of oral minoxidil, while oral minoxidil versus topical 5% was found equally effective. Telemedical data on topical finasteride/minoxidil in 1,545 men showed effectiveness with adverse events in 11.8% and sexual side effects no different from oral finasteride, though adherence was lower. Lyophilized growth factor injections matched PRP for crown transplant density. In 97 alopecia areata patients, oral tofacitinib produced improvement over 50% in 69% with no significant adverse events, though patchy disease responded best.
- Effectiveness and safety of the ablative fractional 2940-nm Er: YAG laser for the treatment of androgenetic alopecia In 192 men with pattern hair loss, adding six sessions of Er:YAG laser to finasteride and minoxidil improved hair counts and thickness versus medication alone.
- The impact of monotherapies for male androgenetic alopecia: A network meta‐analysis study A network meta-analysis of male pattern hair loss monotherapies ranks dutasteride 0.5 mg daily most effective, ahead of oral minoxidil, Botox, microneedling and light therapy.
- Patient‐reported outcomes of topical finasteride/minoxidil treatment for male androgenetic alopecia: A retrospective study using telemedical data Telemedicine data from 1,545 men found topical finasteride/minoxidil effective and well tolerated, with adverse events in 11.8% and sexual side effects no different from oral finasteride, though adherence was lower.
- Oral Drug as Effective as Topical Cream for Male Pattern Baldness A double-blind randomized study of 68 men found oral minoxidil works as well as topical minoxidil 5% for androgenetic alopecia.
- Heat‐treated <i>Limosilactobacillus fermentum</i>LM1020 with menthol, salicylic acid, and panthenol promotes hair growth and regulates hair scalp microbiome balance in androgenetic alopecia: A double‐blind, randomized and placebo‐controlled clinical trial In a 24-week placebo-controlled trial, a topical heat-treated probiotic with menthol, salicylic acid and panthenol increased hair density in pattern hair loss.
- The effect of human lyophilized growth factors versus platelet rich plasma injection on hair transplantation outcome in the crown area of the scalp in men with androgenetic alopecia In 40 men having crown hair transplants, standardized lyophilized growth factor injections performed similarly to PRP for density and satisfaction.
- Reprofiling synthetic glucocorticoid-induced leucine zipper fusion peptide as a novel and effective hair growth promoter The TAT-GILZ peptide promoted hair growth by boosting hair follicle stem cell activity, a novel repurposed hair growth promoter.
- Anti‐hair loss effect of a shampoo containing caffeine and adenosine A 77-person uncontrolled study of a caffeine-plus-adenosine shampoo found increased hair density and reduced shedding, with no change in hair thickness.
- Management of androgenic alopecia: a systematic review of the literature A systematic review of 141 studies finds many oral, topical and procedural treatments promote hair growth in pattern hair loss, favoring individualized combined approaches.
- Injectable platelet-rich fibrin for treatment of female pattern hair loss In 11 women with female pattern hair loss, three sessions of injectable platelet-rich fibrin improved hair counts, volume and thickness with only minor side effects.
- Risk factors and lipid metabolism characteristics of early‐onset male androgenetic alopecia: A pilot study A small study links early-onset male pattern hair loss to low HDL cholesterol, uric acid and vitamin D, plus altered lipid metabolism.
- Safety and efficacy of tofacitinib in 97 alopecia areata patients In 97 alopecia areata patients on oral tofacitinib, 69% improved over 50% and 44% improved 90% or more, with patchy disease responding best and no significant adverse events.
- Risks of alopecia areata in long COVID: Binational population‐based cohort studies from South Korea and Japan In Korean and Japanese cohorts of 22 million people, COVID-19 infection raised the risk of new alopecia areata by 66% for up to 6 months; prior vaccination lowered the risk.
- Enhanced Insights into Frontal Fibrosing Alopecia: Advancements in Pathogenesis Understanding and Management Strategies A review updates pathogenesis and management of frontal fibrosing alopecia, noting treatment lacks standardization.
- Dendrobium officinale polysaccharide promotes angiogenesis as well as follicle regeneration and hair growth through activation of the WNT signaling pathway In mouse follicle and cell cultures, Dendrobium officinale polysaccharide promoted hair follicle growth and angiogenesis by activating WNT signaling.
- Hair growth–promoting effects of Enz_MoriL on human dermal papilla cells through modulation of the Wnt/β-Catenin and JAK-STAT signaling pathways In cultured human dermal papilla cells, mulberry-leaf extract Enz_MoriL promoted growth via Wnt/β-catenin activation and blocked interferon-induced JAK-STAT signaling.
- Gene-Environment Interaction Between <i>CYP1B1</i> and Oral Contraception on Frontal Fibrosing Alopecia A case-control study suggests the protective effect of a CYP1B1 gene variant against frontal fibrosing alopecia depends on past oral contraceptive use.
- Parenting styles and psychological effects on children with alopecia areata: exploring family dynamics, anxiety, and depression A study of 39 children with alopecia areata found more neglectful parenting styles and higher anxiety and depression scores than in controls.
- Alopecia due to chemotherapeutics, hedgehog inhibitors, targeted antibody therapies and immune checkpoint inhibitors A review of drug-induced alopecia: chemotherapy causes hair loss in up to 65% of cases, usually reversible, and scalp cooling can limit taxane-induced loss.
- Deciphering the Complex Immunopathogenesis of Alopecia Areata A review summarizes the genetic, epigenetic and immune drivers of alopecia areata, focusing on loss of follicle immune privilege and T-cell attack.
- ADAM17 variant causes hair loss via ubiquitin ligase TRIM47 mediated degradation A dominant ADAM17 variant causes hypotrichosis with woolly hair via TRIM47-mediated degradation impairing Notch signaling in hair follicle stem cells.
- Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis A review proposes that dysregulated cysteine metabolism may drive hair breakage in alopecia areata, intersecting with autophagy and immunity.
- Melatonin promotes hair regeneration by modulating the Wnt/β‐catenin signalling pathway In mice, melatonin promoted hair regeneration by activating Wnt/beta-catenin signalling between hair follicle stem cells and dermal papillae.
- Health‐related quality of life of adult and adolescent patients living with alopecia areata in Australia An Australian survey of 337 alopecia areata patients found extensive hair loss impairs emotional well-being and work or classroom productivity.
- LncRNA RP11-818O24.3 promotes hair-follicle recovery via FGF2-PI3K/Akt signal pathway In a mouse model of pattern hair loss, a long non-coding RNA reduced in patients restored hair growth via FGF2 and PI3K-Akt signalling.
- Strip Harvesting Follicular Unit Transplantation Versus Follicular Unit Excision: Comparing the Number of Hairs and the Ratio of Hairs to Follicular Unit In patients who had both techniques, follicular unit excision yielded more three-hair grafts and a higher hairs-per-graft ratio than strip harvesting, though neither is declared superior.
- [Research progress in regulation of hair growth by dermal adipose tissue]. A Chinese-language review summarizes how dermal adipose tissue signals regulate hair cycle transitions and hair growth.
- Biotransformation of <i>Cacumen platycladi</i> Extract by <i>Lactiplantibacillus plantarum</i> CCFM1348 Promotes Hair Growth in Mice In mice, a fermented traditional Chinese medicine extract promoted hair growth by activating Wnt/β-catenin signaling, boosting growth factors and reducing apoptosis.
- Psychosocial comorbidities in patients with paediatric alopecia areata: a literature review A systematic review found anxiety, depression and obsessive-compulsive disorder are prevalent in children with alopecia areata and worsen with severity.
- Racial Disparities in Hair Loss Episodes in Patients with Alopecia Areata: A Retrospective Cohort Study A retrospective cohort study examined racial disparities in hair loss episodes among patients with alopecia areata.
- Infectious events in patients with alopecia areata treated with JAK inhibitors: low burden and minimal impact on persistence in treatment In 91 alopecia areata patients on JAK inhibitors, infections occurred in 31% but were mostly manageable; only one patient permanently stopped treatment.
- Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling In mice, reduced GATA3 in skin innate lymphoid cells lets them accumulate around the dermal papilla and facilitate hair follicle recycling.
- Amygdalin ameliorates alopecia areata on C3H/HeJ mice by inhibiting inflammation through JAK2/STAT3 pathway In alopecia areata mice, amygdalin (from a Chinese medicine formula) reduced inflammation via the JAK2/STAT3 pathway and improved hair regrowth.
- <i>Malus pumila</i> Mill. cv Annurca apple extract might be therapeutically useful against oxidative stress and patterned hair loss In cultured human dermal papilla cells, Annurca apple extract reduced oxidative stress and increased hair-growth factors β-catenin and FGF2.
- Crosstalk between endothelial cells and dermal papilla entails hair regeneration and angiogenesis during aging In aged mice, restoring endothelial EDN1-to-dermal papilla signaling promoted hair regeneration while CTF1 signaling promoted angiogenesis.
- Promotion of hair growth by a conditioned medium from human umbilical cord mesenchymal stem cells cultivated in a 3D scaffold of gelatin sponge In mice, conditioned medium from umbilical cord stem cells grown in 3D gelatin sponge promoted hair regrowth and skin angiogenesis.
- Dab2 (Disabled-2), an adaptor protein, regulates self-renewal of hair follicle stem cells In mice, deleting the adaptor protein Dab2 impairs hair follicle stem cell self-renewal, delays the hair cycle and accelerates follicle aging.
- Thyroid receptor β: A promising target for developing novel anti-androgenetic alopecia drugs A review proposes thyroid receptor beta agonists as a future drug target for pattern hair loss, summarizing mechanisms and candidate compounds.
- Postpartum Telogen Effluvium Unmasking Additional Latent Hair Loss Disorders. In 200 women with postpartum hair loss, most also had pattern hair loss, traction alopecia, or both alongside telogen effluvium.
- Autophagy Dysfunction: The Kernel of Hair Loss? A review explores how autophagy and mitophagy in follicle cells may drive hair loss and could be targets for future treatments.
- Italian National Registry of Alopecia Areata: an epidemiological study of 699 Italian patients An Italian registry of 699 alopecia areata patients confirms the disease is chronic-relapsing, unpredictable and significantly impacts quality of life.
- Androgenetic Alopecia in Men: An Update On Genetics A review summarizes the genetics of male pattern hair loss and its links to metabolic and cardiovascular disease.
- Mesotherapy as a Promising Alternative to Minoxidil for Androgenetic Alopecia: A Systematic Review