November 202438
A Delphi consensus of hair specialists issued recommendations on low-dose oral minoxidil covering dosing, contraindications and monitoring. In a randomized trial, adding PRP to hair transplantation improved follicle survival and hair strength in androgenetic alopecia. A retrospective series found FUE transplantation in men gave over 90% follicle survival at 12 months. A systematic review reported injectable minoxidil effective in pattern hair loss. Another review found laser and light therapies increased hair density across alopecia types. In severe alopecia areata, baricitinib against traditional therapies showed greater efficacy at six months, and guidance on ritlecitinib in adolescents reported half reached minimal scalp hair loss by week 48, with headache, acne and nasopharyngitis the most common side effects.
- Low-Dose Oral Minoxidil Initiation for Patients With Hair Loss An international Delphi consensus of 43 hair specialists produced 76 recommendations on dosing, contraindications and monitoring for off-label low-dose oral minoxidil.
- A Prospective and Comparative Study to Explore the Effects of Platelet‐Rich Plasma in Hair Transplantation for Patients With Androgenetic Alopecia In a randomized trial of 30 AGA patients, adding PRP injections to hair transplantation with drug therapy improved follicle survival, growth rates, and hair strength.
- Using the follicular unit extraction technique in treatment of male androgenetic alopecia In a retrospective series of 158 men, FUE hair transplantation gave over 90% follicle survival at 12 months with complications below 6%.
- Restoration of hair follicle inductive properties by depletion of senescent cells In lab studies, senolytic drugs dasatinib and quercetin cleared senescent cells from cultured dermal papilla cells, restoring their ability to regenerate hair follicles.
- Isoquercitrin promotes hair growth through induction of autophagy and angiogenesis by targeting AMPK and IGF-1R In rats, the tea flavonoid isoquercitrin regrew hair by activating AMPK-driven autophagy and IGF-1R-driven blood vessel growth, including in middle-aged animals.
- Comparative Efficacy and Safety of Baricitinib Against Traditional Therapies in Severe Alopecia Areata: A Retrospective Cohort Study In a retrospective cohort of 75 severe alopecia areata patients, baricitinib outperformed traditional treatments at six months; weight gain occurred in 16% on baricitinib.
- MitoQ enhances CYP19A1 expression to stimulate WNT/β-catenin signaling pathway for promoting hair growth in androgenetic alopecia In DHT-treated mice, the mitochondrial antioxidant MitoQ promoted hair growth by boosting CYP19A1 and Wnt/β-catenin signaling in dermal papilla cells.
- Psychological outcomes after hair transplant in women with androgenetic alopecia a study of psychological outcomes after hair transplantation in women with androgenetic alopecia.
- Patient Considerations when Using Ritlecitinib for Alopecia Areata in Adolescents: Guidance for the Clinicians A clinical guidance review reports ritlecitinib 50 mg daily got 25% of adolescents with severe alopecia areata to minimal scalp hair loss by week 24, rising to 50% by week 48, with headache, acne and nasopharyngitis the most common side effects.
- Efficacy and Safety of Laser Therapy and Phototherapy in Cicatricial and NonCicatricial Alopecia: A Systematic Review Study A systematic review of 58 studies found laser and light therapies increased hair density and diameter across alopecia types, with possible added benefit alongside minoxidil.
- Injectable Minoxidil for Hair Loss Disorders: A Systematic Review A systematic review found injectable minoxidil effective and safe for androgenetic alopecia, with variable results in alopecia areata.
- A Well‐Tolerated Hair Serum Containing New Natural Active Ingredients Reduced Hair Loss and Improved Quality of Life in Women With Chronic Telogen Effluvium: A 16‐Week Controlled Study In a 16-week controlled study of 64 women with chronic telogen effluvium, a plant-based serum reduced hair shedding and improved quality of life.
- New Plant Extracts Exert Complementary Anti‐Hair Loss Properties in Human In Vitro and Ex Vivo Models In human cell and scalp skin models, three plant-derived ingredients activated growth pathways, reduced 5α-reductase activity and prolonged the hair growth phase.
- Comparative analysis of temperature‐controlled cryotherapy versus intralesional triamcinolone acetonide injection for alopecia areata: An intrasubject split‐lesion pilot study a split-lesion pilot study comparing temperature-controlled cryotherapy with intralesional triamcinolone injections for alopecia areata.
- Frontal Fibrosing Alopecia: A Comprehensive Guide for Cosmetic Dermatologists A review advises that non-ablative lasers, fat injections and oral isotretinoin can help FFA skin changes, while deep peels and ablative lasers risk scarring.
- Gpr54 deletion accelerates hair cycle and hair regeneration In mice, deleting the kisspeptin receptor Gpr54 sped the hair cycle and boosted regrowth by lifting Wnt pathway brakes in dermal papilla cells.
- Identification and characterization of alopecia areata subgroups regarding quality of life impairment based on demographic, clinical, psychological, and social factors A survey of 322 people with alopecia areata found the worst quality-of-life impairment in those who felt flawed and coped by avoidance.
- Continued treatment with baricitinib results in meaningful scalp responses among scalp non‐responder patients with eyebrow/eyelash regrowth in the first year continued baricitinib produced meaningful scalp responses in patients who had regrown eyebrows or eyelashes but not scalp hair in the first year.
- Hair loss in athletic testosterone use in males: a narrative review A narrative review examines links between athletic testosterone use and male hair loss, noting the absence of standardized safe-dose guidelines.
- Investigation the role of SIRT3, SIRT7, NFATC1, and PDL-1 genes in androgenetic alopecia In scalp stem cells from six men with AGA, aging-related genes SIRT3 and SIRT7 were reduced while NFATC1 and PDL-1 were elevated.
- Restoration of follicular β-catenin signaling by mesenchymal stem cells promotes hair growth in mice with androgenetic alopecia In AGA-model mice, transplanted umbilical cord mesenchymal stem cells promoted hair growth by reducing dermal papilla cell apoptosis via Wnt/β-catenin signaling.
- Force-triggered density gradient sedimentation and cocktail enzyme digestion treatment for isolation of single dermal papilla cells from follicular unit extraction harvesting human hair follicles Two new isolation techniques yielded fresher, more authentic dermal papilla cells from transplanted-type human hair follicles than traditional methods.
- FR – Actualización en el tratamiento farmacológico de alopecia androgenética en pacientes transgénero a Spanish-language update on drug treatment of androgenetic alopecia in transgender patients.
- Minoxidil oral en dosis bajas en alopecia frontal fibrosante: serie de 122 pacientes In a 122-patient retrospective series, low-dose oral minoxidil improved frontotemporal hairline density in 45% of frontal fibrosing alopecia patients; hypertrichosis occurred in 24%.
- An <i>eGFP-Col4a2</i> mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis In a fluorescent mouse model, live imaging showed basement membrane collagen turnover gradients guide progenitor behavior and shape developing hair follicles.
- Line‐field confocal optical coherence tomography in alopecia areata and histopathological correlation a study of line-field confocal optical coherence tomography imaging in alopecia areata and its correlation with histopathology.
- Scalp condition improvement with botanical extracts possessing chemical and physical antioxidant activity In lab and consumer tests, antioxidant botanical extracts such as rosemary reduced scalp lipid oxidation, suggesting improved scalp condition from hair-care products.
- JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia In mice, blocking JAK1/2 or STAT1 calmed inflammation and restarted hair growth after EGFR loss, with matching signals seen in human scarring alopecia biopsies.
- Budget impact analysis of baricitinib for treatment of alopecia areata: A Saudi hospital perspective Adding baricitinib to a Saudi hospital formulary for severe alopecia areata would raise five-year costs from about 5.8 to 7.5 million riyals.
- Effect of gelatin nanoparticles’ size and charge on iontophoretic targeted deposition to the hair follicles In pig skin, larger positively charged gelatin nanoparticles penetrated deepest into hair follicles under iontophoresis, a possible route for future follicle-targeted drugs.
- Complete responses and SALT zero scores in alopecia areata: not the same complete response and a SALT zero score are not equivalent outcomes in alopecia areata.
- Evaluating Anti-Inflammatory Potential of Platelet-Rich Plasma in Scarring Alopecia: A Systematic Review A systematic review found platelet-rich plasma may slow scarring alopecia progression, but evidence rests on case reports and immunomodulatory drugs remain first-line.
- A Randomized, Placebo-controlled Clinical Study Evaluating a Dietary Supplement for Hair Growth. In a 65-woman placebo-controlled trial, a daily B-vitamin, zinc and botanical gummy improved hair density and self-assessed hair quality over six months, with no adverse events.
- Preparation and evaluation of hair growth promoting effect of transferosomes containing red clover extract and caffeine alone or in combination. In mice, transferosome gels of caffeine or red clover extract matched minoxidil 2% for hair growth after three weeks, but combining them added no benefit.
- Dissecting Cellulitis Presenting After Hair Restoration Surgery
- Defense‐related callose synthase PMR4 promotes root hair callose deposition and adaptation to phosphate deficiency in Arabidopsis thaliana
- A Qualitative Review of Misinformation on Alopecia
- An Overview of Commonly Used Natural Alternatives for the Treatment of Androgenetic Alopecia, with Special Emphasis on Rosemary Oil