February 202429
Keratin microspheres applied topically regrew hair in mice and increased growth markers in human dermal papilla cells. β-Nicotinamide mononucleotide countered DHT-driven follicle damage in mice and human cells, promoting hair growth comparable to minoxidil. Bee venom–treated adipose stem cells injected into mice accelerated hair regrowth by boosting growth factor release. A review concluded that baricitinib's approval for alopecia areata opened a new treatment era, with regrowth building over months.
- A new era for alopecia areata: New treatments and improved knowledge of the condition A review describes how baricitinib's approval opened a new treatment era for alopecia areata, with regrowth building over months and more JAK drugs coming.
- Keratin Microspheres as Promising Tool for Targeting Follicular Growth Topical keratin microspheres regrew hair in mice and boosted growth markers in human dermal papilla cells in a lab study.
- β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress In mice and human dermal papilla cells, NMN countered DHT-driven follicle damage and promoted hair growth comparable to minoxidil.
- Bee Venom Stimulates Growth Factor Release from Adipose-Derived Stem Cells to Promote Hair Growth Bee venom–treated adipose stem cells injected into mice accelerated hair regrowth by boosting growth factor release.
- <i>In Vitro</i> and <i>In Vivo</i> Models for the Development of Hair Growth Materials By Regulating the <i>β</i>-Catenin Signaling Pathways A β-catenin inhibitor suppressed hair growth in mice and dermal papilla cells, providing a model for screening hair-growth compounds.
- Alopecia areata: Line‐field confocal optical coherence tomography features and dermoscopy correlation LC-OCT imaging in 65 alopecia areata patients visualized dermoscopic features like yellow dots, broken hairs and black dots at high resolution.
- Role of systemic minoxidil in the treatment of alopecia areata: A scoping review to direct future research A scoping review maps the evidence on systemic minoxidil for alopecia areata to direct future research.
- Hair Rub Test - A Novel Method to Assess Hair Loss A novel 'hair rub test' with damp gauze showed declining shed hairs across PRP sessions in 30 patients, proposed as a patient-friendly shedding measure.
- Diffuse pattern of alopecia areata in children: A multicentre retrospective study with 67 patients A multicentre retrospective study of 67 children examines the diffuse pattern of alopecia areata.
- Nutraceuticals known to promote hair growth do not interfere with the inhibitory action of tamoxifen in MCF7, T47D and BT483 breast cancer cell lines In breast cancer cell lines, nine hair-growth nutraceuticals did not interfere with tamoxifen's estrogen-blocking action; more research is needed to confirm safety and efficacy in patients.
- Recent progress in hair follicle stem cell markers and their regulatory roles A review catalogues hair follicle stem cell molecular markers and their regulatory roles, drawing on single-cell transcriptomics data.
- Interleukin gene polymorphisms and alopecia areata: A systematic review and meta-analysis A meta-analysis of eight studies links the IL2RA rs3118470 variant to higher alopecia areata risk; other interleukin variants showed no association.
- Hair follicle stem cells promote epidermal regeneration under expanded condition Hair follicle stem cells promoted epidermal regeneration under skin expansion conditions in this mechanistic study.
- Decreased CD19+CD24hiCD38hi Regulatory B Cells in Alopecia Areata Patients with alopecia areata had fewer IL-10-producing regulatory B cells than healthy controls, regardless of clinical subtype.
- Clinical Characterization and Treatment Response of Folliculitis Decalvans Lichen Planopilaris Phenotypic Spectrum: A Unicentre Retrospective Series of 31 Patients In a 31-patient series of folliculitis decalvans–lichen planopilaris overlap, anti-inflammatory lichen planopilaris treatments appeared adequate, though nine relapses occurred.
- Autologous follicular unit extraction transplant for postburn cicatricial alopecia: A single‐center's retrospective case series In a 41-patient retrospective series, FUE transplantation for burn-related scarring alopecia gave natural growth, high satisfaction and few complications.
- Identification of SLC40A1, LCN2, CREB5, and SLC7A11 as ferroptosis-related biomarkers in alopecia areata through machine learning Machine learning identified four ferroptosis-related genes as candidate diagnostic markers for alopecia areata with high model accuracy.
- In Silico Study on the Contribution of the Follicular Route to Dermal Permeability of Small Molecules A computer model found the hair follicle's contribution to skin permeability of small molecules ranges from negligible to notable depending on compound properties.
- Dupliumab therapy for alopecia areata: a case series and review of the literature In a 10-patient case series, dupilumab gave at least 50% regrowth in seven alopecia areata patients, often with initially white regrowth, and was well tolerated.
- Tumor necrosis factor inhibitors and janus kinase inhibitors in the treatment of cicatricial alopecia: A systematic review A systematic review of 56 studies found oral tofacitinib and adalimumab most effective for scarring alopecias with mostly tolerable adverse effects, but regular monitoring is advised and further studies are needed before definitive recommendations.
- The Alopecia Areata Severity and Morbidity Index (ASAMI) Study An expert Delphi consensus identified factors beyond scalp loss—duration, relapses, facial hair and nail involvement, quality of life—that worsen alopecia areata severity.
- The development of an in vitro human hair follicle organoid with a complexity similar to that in vivo Researchers built a lab-grown human hair follicle organoid that elongates like real follicles and responds to growth enhancers and inhibitors, enabling high-throughput screening.
- Extemporaneous Topical Minoxidil Solutions for the Treatment of Androgenetic Alopecia- Stability Studies and Incorporation Tests of Active Pharmaceutical Ingredients in Aloplus Total Base. Compounded 8% minoxidil lotions in a propylene glycol-free base stayed chemically and physically stable for over 180 days in lab tests.
- Dihydrotestosterone inhibits hair growth in mice by inhibiting insulin-like growth factor-I production in dermal papillae In mice, DHT reduced IGF-I production in dermal papillae by blocking sensory neuron stimulation, inhibiting hair regrowth.
- Topical tofacitinib for patients with lichen planopilaris and/or frontal fibrosing alopecia Topical tofacitinib was tried in patients with lichen planopilaris and/or frontal fibrosing alopecia.
- Transcriptome analysis of frontal fibrosis alopecia revealed involvement of immune cells and ferroptosis Transcriptome analysis of frontal fibrosing alopecia lesions implicated immune cell activation and ferroptosis in its mechanism.
- Hair repigmentation of poliosis circumscripta in androgenetic alopecia patient treated with exosomes and fractional picosecond laser
- The Hormonal Background of Hair Loss in Non-Scarring Alopecias
- The role of fractional laser‐assisted drug delivery in enhancing the efficacy of topical bimatoprost solution in the treatment of alopecia areata: An intra‐patient comparative randomized clinical trial