January 202442
A 1565 nm fractional laser was reported to improve density more than 5% minoxidil, and adding microneedling to treatment improved density and diameter over monotherapy. In Chinese women, a laser helmet with minoxidil improved midscalp diameter more than minoxidil alone. Platelet-rich plasma versus minoxidil was rated more effective by investigators, though minoxidil produced more negative hair pull tests. A smoking meta-analysis found smokers had 82% higher odds of pattern hair loss. Baricitinib 4 mg for alopecia areata ranked most effective in a network meta-analysis, and ritlecitinib safety data showed mostly mild adverse events, though serious events occurred in 4.4% with two deaths.
- Investigator‐blinded, controlled, and randomized comparative study on 1565 nm non‐ablative fractional laser versus 5% minoxidil for treatment of androgenetic alopecia In a 30-patient trial, 1565 nm non-ablative fractional laser improved hair density and count more than 5% minoxidil at 10 weeks.
- Efficacy and safety of combined microneedling therapy for androgenic alopecia: A systematic review and meta‐analysis of randomized clinical trials A meta-analysis of 13 randomized trials found microneedling combined with other treatments improved hair density and diameter more than monotherapy, with similar safety.
- Comparative Efficacy of 2% Minoxidil Alone Against Combination of 2% Minoxidil and Low-level Laser therapy in Female Pattern Hair Loss-A Randomized Controlled Trial in Chinese females In Chinese women with pattern hair loss, adding a 655 nm laser helmet to 2% minoxidil improved midscalp hair diameter more than minoxidil alone.
- A meta‐analysis study on the association between smoking and male pattern hair loss A meta-analysis of eight studies found smokers have 82% higher odds of pattern hair loss and modestly faster progression than never-smokers.
- Efficacy of Platelet-Rich Plasma versus 5% Topical Monixidil for the Treatment of Androgenetic Alopecia In a 70-patient trial, PRP beat 5% minoxidil on investigator-rated effectiveness (74.5% vs 43.7%), though minoxidil produced more negative hair pull tests.
- The Value of Trichoscopy in the Follow-up of Treatment Response in Patients with Androgenetic Alopecia. Trichoscopy performed by an experienced doctor matched TrichoScan for tracking hair counts, supporting its use in monitoring androgenetic alopecia treatment response.
- Comparative efficacy of oral Janus kinase inhibitors and biologics in adult alopecia areata: A systematic review and Bayesian network meta‐analysis A network meta-analysis ranked baricitinib 4 mg as the most effective alopecia areata therapy, ahead of ritlecitinib; biologics like dupilumab performed poorly.
- Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program Across 1294 alopecia areata patients, ritlecitinib's common adverse events were headache, COVID-19, and nasopharyngitis over up to 24 months, though serious events occurred in 4.4% and two deaths were reported.
- Baricitinib Therapy for Moderate to Severe Alopecia Areata: A Retrospective Review of 95 Japanese Patients a retrospective review of baricitinib treatment in 95 Japanese patients with moderate-to-severe alopecia areata.
- Ginsenosides in <i>Panax ginseng</i> Extract Promote Anagen Transition by Suppressing BMP4 Expression and Promote Human Hair Growth by Stimulating Follicle-Cell Proliferation In human follicle cells, Panax ginseng ginsenosides promoted anagen transition and hair-shaft growth by suppressing BMP4.
- Cocktail Cell‐Reprogrammed Hydrogel Microspheres Achieving Scarless Hair Follicle Regeneration In vitro and in vivo, reprogrammed hydrogel microspheres converted fibroblasts into dermal papilla cells, achieving scarless hair follicle regeneration.
- Short-Term Clinical Assessment of Treating Female Androgenic Alopecia with Autologous Stem Cells Derived from Human Hair Follicles In 23 women with pattern hair loss, a single injection of autologous hair follicle stem cell micrografts improved hair condition six months later.
- Divergent progression pathways in male androgenetic alopecia and female pattern hair loss: Trichoscopic perspectives A trichoscopy study of 183 patients suggests male pattern loss begins with hair-shaft thinning while female pattern loss begins with fewer hairs per follicular unit.
- Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche A mouse and human tissue study: skin-resident regulatory T cells protect the hair follicle stem cell niche, with aberrant IL-2 signaling found in alopecia areata.
- Recovery Effects of <i>Nephelium lappaceum</i> var. <i>pallens</i> (Hiern) Leenh. Extract on Testosterone-Induced Inhibition of Hair Growth in C57BL/6 Mice and Human Follicular Dermal Papilla Cells In mice and human dermal papilla cells, rambutan extract restored testosterone-inhibited hair growth more effectively than finasteride.
- Traditional Scraping (Gua Sha) Combined with Copper‐Curcumin Nanoparticle Oleogel for Accurate and Multi‐Effective Therapy of Androgenic Alopecia Copper-curcumin nanoparticle gel combined with scraping (Gua Sha) outperformed minoxidil for hair regrowth in a mouse model of androgenetic alopecia.
- European expert consensus statement on the systemic treatment of alopecia areata A European consensus recommends systemic treatment for alopecia areata from SALT 20, with approved baricitinib and ritlecitinib; oral minoxidil only as adjuvant.
- Novel Application of 1064-nm Picosecond Nd:YAG Laser for Male Androgenetic Alopecia Treatment. In five men with pattern hair loss, three 1064-nm picosecond laser sessions promoted regrowth with minimal side effects resolving within a week.
- A Clinical Trial Shows Improvement in Skin Collagen, Hydration, Elasticity, Wrinkles, Scalp, and Hair Condition following 12‐Week Oral Intake of a Supplement Containing Hydrolysed Collagen A 12-week randomized trial: a hydrolysed collagen supplement improved skin measures and hair appearance scores, but the 27.6% hair count increase was not statistically significant.
- Factors Affecting the Response and Patient Satisfaction of Topical Immunotherapy in Alopecia Areata: A Nationwide Study A 412-patient Korean study: DPCP immunotherapy for alopecia areata worked best treating the whole scalp; atopy and thyroid disease predicted poorer response.
- Dickkopf-related Protein 2 Promotes Hair Growth by Upregulating the Wnt/β-catenin Signaling Pathway in Human Dermal Papilla Cells In human dermal papilla cells and hair follicle cultures, DKK2 protein promoted hair growth via Wnt/β-catenin signaling, matching minoxidil's effect on cell proliferation.
- Retrospective Analysis of the Effect of Comorbid Atopic Dermatitis on the Treatment Response to Topical Immunotherapy in Pediatric Alopecia Areata Patients In 139 children with alopecia areata, topical immunotherapy worked in 57%, and coexisting atopic dermatitis predicted a poor response.
- Evaluating the Effect of the Demographic, Trichoscopic and Laboratory Characteristics on The Recurrence of Alopecia Areata In 100 alopecia areata patients, male sex and family history independently predicted recurrence, alongside longer disease duration, hypothyroidism, and folic acid deficiency.
- Treatment of moderate-to-severe alopecia areata in patients over the age of 65 with baricitinib In 14 patients over 65 with moderate-to-severe alopecia areata, baricitinib reduced SALT scores by 72% with only mild adverse effects.
- Baricitinib for the treatment of alopecia areata in adults: Real-world analysis of 36 patients A real-world analysis of baricitinib treatment in 36 adults with alopecia areata.
- Mendelian randomization study highlights hypothyroidism as a causal determinant of alopecia areata A Mendelian randomization analysis found genetic evidence that hypothyroidism causally increases the risk of alopecia areata.
- Post–Hair Transplantation Complication: Kinky or Severely Curly Hair A 980-patient study: 3.9% developed curly hair growth after female hairline transplant, usually appearing around four months post-surgery.
- Minoxidil delivered via a stem cell membrane delivery controlled release system promotes hair growth in C57BL/6J mice In mice, minoxidil loaded into stem-cell-membrane nanoparticles penetrated skin better and promoted hair growth more than ordinary minoxidil.
- Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration A review covers molecular mechanisms governing hair follicle stem cell activity and regeneration.
- Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis A lab study found autophagy activates hair follicle stem cells and regeneration by shifting metabolism toward glycolysis.
- Frontal Fibrosing Alopecia and Reproductive Health: Assessing the Role of Sex Hormones in Disease Development A narrative review links fewer fertile years and abrupt hormonal disruption to frontal fibrosing alopecia, though the mechanisms remain debated.
- Development and Evaluation of Dutasteride Nanoemulgel for the Topical Delivery against Androgenic Alopecia A topical dutasteride nanoemulgel grew new follicles and thicker hair in mice, suggesting a lower-systemic-exposure delivery option for androgenetic alopecia.
- Topical sodium valproate-loaded nanospanlastics versus conventional topical steroid therapy in alopecia areata: a randomized controlled study In 66 patients with patchy alopecia areata, topical sodium valproate nanospanlastics matched topical steroids, both showing only modest efficacy.
- Methionine Dependence of Hair Maintenance in C57BL/6 Mice In mice, a methionine-deficient diet caused hair loss that only dietary methionine, not homocysteine, reversed.
- A comparative study of fractional CO2 laser with topical triamcinolone acetonide versus intralesional triamcinolone acetonide in the treatment of alopecia areata In a 60-patient trial, fractional CO2 laser with topical triamcinolone beat intralesional triamcinolone for patchy alopecia areata, avoiding skin atrophy.
- Korean Consensus Criteria for the Severity Classification of Alopecia Areata Korean consensus defined severe alopecia areata as SALT 50 or higher and moderate as SALT 20–49, with quality-of-life criteria for upgrading.
- Therapeutic Response of Alopecia Areata‐Associated Nail Changes to Baricitinib A case report: a patient's alopecia areata-associated nail dystrophy normalized after 11 months of baricitinib treatment.
- Concurrent Eosinophilia Increases the Prevalence of Nail Abnormalities and Severity of Hair Loss in Patients With Alopecia Areata Alopecia areata patients with eosinophilia had more nail abnormalities and 3.7-fold higher odds of severe hair loss.
- Survey on Alopecia Areata Patients’ Reported Factors that Determine Severity of Alopecia Areata: A Nationwide Multicenter Study A survey of 791 Korean patients: those with alopecia areata viewed ≥20% scalp loss, long duration and body-hair involvement as markers of severe disease.
- Molecular Mechanisms of Hair Follicle Development A review summarizing the Wnt, Shh, Notch and BMP signaling pathways that govern hair follicle development and cycling.
- Evaluation of the relationship of digital phototrichogram findings of patients with diffuse hair loss with blood TSH, ferritin and vitamin B12 levels
- Keratosis Follicularis Squamosa in Unilateral Buttock: A Case Report and Review of Literature in China