December 202338
Fractionated laser therapy for pattern hair loss thickened hair shafts without raising hair count, while single-spin and double-spin PRP both improved hair density. FUE hair transplantation improved quality of life and reduced stress in pattern-hair-loss patients, and a review concluded FUE's long learning curve means unskilled clinics cause permanent donor damage. Baricitinib for refractory alopecia areata cut SALT scores with favorable safety, though the study was open-label and single-center. Tofacitinib for alopecia areata was effective in most patients, with shorter disease duration predicting response and no severe adverse events observed, though the study was retrospective and single-center.
- Use of fractionated laser therapy for the treatment of androgenetic alopecia: a systematic review and meta-analysis A meta-analysis found fractionated laser therapy, especially erbium-glass, improves hair shaft thickness in pattern hair loss but does not increase hair count.
- Comparing Single-spin Versus Double-spin Platelet-rich Plasma (PRP) Centrifugation Methods on Thrombocyte Count and Clinical Improvement of Androgenetic Alopecia: A Preliminary, Randomized, Double-blind Clinical Trial. In a 30-man randomized trial, single- and double-spin PRP both raised platelet counts 4-5 fold and improved hair density and count; either method works.
- Discovery of (2<i>S</i>)-<i>N</i>-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment A new topical androgen receptor antagonist (compound 30a) promoted hair growth in mouse AGA models with high skin and low plasma exposure.
- Effectiveness and safety of baricitinib in patients with moderate‐to‐severe refractory alopecia areata in real world: An open‐label, single‐center study In 32 patients with refractory moderate-to-severe alopecia areata, 24 weeks of baricitinib cut SALT scores substantially with favorable safety.
- Impact of Hair Transplantation on Quality of Life In 48 AGA patients, FUE hair transplantation significantly improved quality of life, life satisfaction, stress and anxiety.
- Effectiveness and Predictive Factors of Response to Tofacitinib Therapy in 125 Patients with Alopecia Areata: A Single-centre Real-world Retrospective Study In 125 alopecia areata patients, tofacitinib was effective in 83%, with shorter disease duration predicting response and no severe adverse events observed.
- Molybdenum Nanoparticles as a Potential Topical Medication for Alopecia Treatment through Antioxidant Pathways that Differ from Minoxidil Nano-molybdenum accelerated hair growth in mice via antioxidant pathways and showed additive effect combined with minoxidil.
- Paradigm Shift from Linear Strip to Follicular Unit Excision in Hair Restoration Surgery A review argues FUE is real surgery with a long learning curve, warning that 'scarless' marketing and unskilled clinics cause permanent donor damage.
- Cyanidin-3-O-glucoside and its derivative vitisin A alleviate androgenetic alopecia by exerting anti-androgen effect and inhibiting dermal papilla cell apoptosis Cyanidin-3-O-glucoside and vitisin A creams blocked androgen receptors and reversed DHT-induced follicle miniaturization in mice.
- Refractory alopecia areata with single hairs imitating frontal fibrosing alopecia: a prospective observational study An 18-patient study describes alopecia areata mimicking frontal fibrosing alopecia with single hairs and poor response to conventional therapy.
- Chitosan and its amphiphilic derivative nanoparticles loaded with Minoxidil for induction of hair growth: In vitro and in vivo evaluation Chitosan-derivative nanoparticles carrying minoxidil boosted hair growth in mice more than commercial formulation, aiming to cut solvent-related irritation.
- Justicia procumbens prevents hair loss in androgenic alopecia mice Justicia procumbens extract activated Wnt/β-catenin in dermal papilla cells and reduced hair loss in testosterone-induced AGA mice.
- Hair Growth-Promoting Effects of Rosehip (<i>Rosa canina</i> L.) Seed Oil in C57BL/6 Mice Rosehip seed oil promoted hair regrowth in mice by pushing follicles into anagen and upregulating growth genes like β-catenin and Shh.
- USE OF RITLECITINIB FOR THE TREATMENT OF ALOPECIA AREATA A letter reviews FDA-approved ritlecitinib for alopecia areata in patients 12 and older, citing phase 2b/3 trial results and common side effects.
- The new era of JAK inhibitors: Impelling updates in Alopecia Areata Guideline a review updating alopecia areata guidelines for the new era of JAK inhibitors.
- Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview A review outlines how programmed cell death (apoptosis) drives hair follicle regression and shedding and its role in hair loss.
- A CASE-CONTROL STUDY TO ASSESS THE ASSOCIATION OF ALOPECIA AREATA WITH THYROID DYSFUNCTION AND THYROID AUTOIMMUNITY A case-control study linked alopecia areata to thyroid autoimmunity but not to clinical thyroid dysfunction.
- A clinical investigation of early‐onset alopecia areata in children: Onset earlier than 4 years of age might have a better short‐term prognosis In 162 children with early-onset alopecia areata, 57% regrew half their hair; onset before age 4 responded significantly better.
- Biological and mechanical influence of three-dimensional microenvironment formed in microwell on multicellular spheroids composed of heterogeneous hair follicle stem cells A lab study examines how microwell geometry affects 3D spheroids grown from hair follicle stem cells.
- Beard and Body Hair Transplantation by Follicular Unit Excision Using a Skin-Responsive Device: A Multicenter Study A multicenter series reports a skin-responsive FUE device achieved low transection rates harvesting beard and body hair for donor-limited transplant patients.
- MiR-199a-3p Regulates the PTPRF/β-Catenin Axis in Hair Follicle Development: Insights into the Pathogenic Mechanism of Alopecia Areata In sheep follicles and mice, miR-199a-3p promoted hair growth via PTPRF/beta-catenin, and blocking it induced alopecia areata-like changes.
- Human Hair Graying Revisited: Principles, Misconceptions, and Key Research Frontiers A review explains hair graying via oxidative damage, melanocyte loss and mTORC1 activity, noting drug-induced repigmentation hints at reversible pathways.
- Treatment preferences of adults and adolescents with alopecia areata: A discrete choice experiment A survey found alopecia areata patients, especially adolescents, would accept substantial risks of JAK inhibitors for meaningful scalp regrowth.
- Degree of Alignment Between Japanese Patients and Physicians on Alopecia Areata Disease Severity and Treatment Satisfaction: A Real-World Survey A Japanese real-world survey found patients and physicians often misaligned on alopecia areata severity and treatment satisfaction.
- The effect of oxygen supply using perfluorocarbon-based nanoemulsions on human hair growth In lab-grown human hair, oxygen-carrying perfluorocarbon nanoemulsions increased hair shaft elongation about fourfold under low-oxygen conditions.
- pH STIMULUS-RESPONSIVE HYBRID NANOPARTICLES: A SYSTEM DESIGNED FOR FOLLICULAR DELIVERY OF BRAZILIAN PLANT-DERIVED 5-ALPHA-REDUCTASE ENZYME INHIBITORS Lab-made pH-responsive nanoparticles delivered plant-derived 5-alpha-reductase inhibitors to hair follicle depths with low cytotoxicity in vitro.
- Characteristics of hair loss in COVID-19 patients in Thailand. In 43 Thai patients, hair loss after COVID-19 was mostly telogen effluvium starting around 30 days post-infection; women shed more severely.
- Spatial Distribution and Functional Impact of Human Scalp Hair Follicle Microbiota Lab mapping of scalp follicle microbes found compartment-specific colonizers; bacterial metabolite butyrate delayed catagen ex vivo.
- The Incidence of Alopecia Areata in a COVID-19-Vaccinated Population: A Single-Center Review A single-center review found COVID-19 vaccination was not associated with increased alopecia areata incidence; vaccinated individuals had lower odds (OR 0.58), a finding from one center only.
- Establishment and characterization of matched immortalized human frontal and occipital scalp dermal papilla cell lines from androgenetic alopecia Researchers built matched frontal and occipital dermal papilla cell lines from AGA patients, showing frontal cells inhibit hair growth, as a research resource.
- Progress on the mechanism of natural products alleviating androgenetic alopecia A review maps how natural products might treat pattern hair loss via Wnt/β-catenin, PI3K/AKT and anti-inflammatory pathways, but offers no clinical evidence.
- Follicular Unit Excision Donor Area Management and Considerations of the Scalp A review discusses how surgeons can preserve donor-area appearance across repeated FUE harvests in transplant patients.
- Safety and efficacy of hair growth promoting product in adult human subject having hair fall complaints (alopecia) In 32 adults with hair fall, a peptide-based hair serum improved growth rate, density and thickness over 60 days with no adverse events reported.
- Teledermatology in Alopecia: A Systematic Review A systematic review examines the use of teledermatology for diagnosing and managing alopecia.
- Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via the β2 adrenergic pathway suppression In stressed mice, rhynchophylline cut hair graying from 28.5% to 8.2% by blocking the β2-adrenergic pathway in melanocyte stem cells.
- No-Shave Long Hair Follicular Unit Excision Using an All-Purpose Skin-Responsive Device In 152 patients, a skin-responsive device performed no-shave long-hair FUE with low transection and shaft-break rates and high patient satisfaction.
- Oral Minoxidil Media Coverage: The Impact on Patient Perceptions and Practitioner Approaches to Androgenetic Alopecia An examination of how media coverage of oral minoxidil affects patient perceptions and practitioner approaches to androgenetic alopecia.
- A description of alopecia areata in European patients based on real-world survey data: physician-reported characterization of severity and associated treatment utilization A five-country survey of 2,083 European patients showed corticosteroids dominate mild alopecia areata care while immunosuppressants and JAK inhibitors rise with severity.