September 202359
Gene analysis in Romanian and Brazilian patients suggested minoxidil suitability in half of cases and dutasteride or latanoprost benefit based on SRD5A1 and PTGFR-2. A topical finasteride review concluded it appears safe and effective while avoiding systemic side effects, though optimal strength and long-term data are lacking. Adding microneedling to topical minoxidil significantly increased hair count in a meta-analysis, with hair-diameter gains unproven. PRP injections produced more negative hair-pull tests than 5% topical minoxidil. Occipital involvement in Saudi women was found in one-third, limiting donor supply for transplantation. Stem cell exosomes reversed DHT's inhibition of hair follicle growth via Wnt/β-catenin in human follicles, cells and mice.
- Medication-induced hair loss: An update A review updates which medications cause hair loss.
- Epidemiologic Study of Gene Distribution in Romanian and Brazilian Patients with Non-Cicatricial Alopecia In Romanian and Brazilian patients, gene analysis suggested minoxidil suitability in half of cases and dutasteride or latanoprost benefit based on SRD5A1 and PTGFR-2.
- Topical Finasteride: A Comprehensive Review of Androgenetic Alopecia Management for Men and Women A review concludes topical finasteride for androgenetic alopecia appears safe and effective while avoiding systemic finasteride side effects, but optimal strength and long-term data are lacking.
- Efficacy and safety of combinational therapy using topical minoxidil and microneedling for the treatment of androgenetic alopecia: a systematic review and meta-analysis A meta-analysis of eight trials found adding microneedling to topical minoxidil significantly increased hair count with no serious adverse events, though hair-diameter gains were unproven.
- A Randomized Control Trial Comparing the Efficacy of Platelet-Rich Plasma and 5% Topical Minoxidil for the Treatment of Androgenetic Alopecia. A randomized trial in Pakistan found PRP injections produced more negative hair-pull tests than 5% topical minoxidil after 12 weeks (91.7% vs 69.4%).
- Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/β-Catenin Pathway Stem cell exosomes reversed DHT's inhibition of hair follicle growth via Wnt/β-catenin in human follicles, cells and mice.
- TLR2 regulates hair follicle cycle and regeneration via BMP signaling In mice, TLR2 maintains hair follicle stem cell activation; its ligand CEP, reduced in aging and obesity, stimulates hair regeneration when administered.
- Efficacy of autologous dermal sheath cup cell transplantation in male and female pattern hair loss: A Single‐Arm, Multi‐Center, phase III equivalent clinical study In a 36-person single-arm study, injected dermal sheath cup cells gave visible improvement in 30% and small hair-diameter gains with no serious adverse events.
- Analysis of 72,469 UK Biobank exomes links rare variants to male-pattern hair loss Exome analysis of 72,469 UK Biobank men linked five genes (EDA2R, WNT10A, HEPH, CEPT1, EIF3F) to male-pattern hair loss, though rare variants explain little overall risk.
- Real-Life Effectiveness and Tolerance of Baricitinib for the Treatment of Severe Alopecia Areata with 1-Year Follow-Up Data In a 19-patient real-world series, over 70% of severe alopecia areata patients reached near-complete scalp coverage on baricitinib, with relapse risk after stopping and lipid changes the commonest side effect.
- Efficacy of Dr. SKS Hair Booster Serum in the Treatment of Female Pattern Alopecia in Patients With PCOS: An Open-Label, Non-randomized, Prospective Study In 1,000 women with PCOS-related pattern hair loss, monthly scalp Dr. SKS Hair Booster Serum treatments improved hair diameter and terminal counts over six months; the study was open-label without controls.
- Evaluation of efficacy of <i>Silybum marianum</i> flower extract on the mitigating hair loss in vitro and in vivo A milk thistle flower extract shampoo increased hair density and total hair count versus placebo over 24 weeks, supported by dermal papilla cell studies.
- When to expect scalp hair regrowth during treatment of severe alopecia areata with baricitinib: insights from trajectories analyses of patients enrolled in two phase III trials Post hoc analysis of two phase III trials found baricitinib responders fall into early, gradual and late regrowth groups, with faster response in less severe, shorter-duration alopecia areata.
- Utilization of response surface design for development and optimization of rosuvastatin calcium-loaded nano-squarticles for hair growth stimulating VEGF and IGF production: <i>in-vitro</i> and <i>in-vivo</i> evaluation In rats, rosuvastatin-loaded nanoparticles regrew hair faster than 5% minoxidil by raising VEGF and IGF-1 levels.
- Review of Baricitinib in the Treatment of Alopecia Areata. A review reports 36–39% of severe alopecia areata patients on baricitinib 4 mg achieved near-full scalp regrowth in two phase III trials versus 3–6% on placebo.
- Association Between Trichoscopic Features and Serum Hormone Levels and Vitamin D Concentration in Patients with Androgenetic Alopecia in Eastern China: A Cross-Sectional Study In 310 Chinese AGA patients, lower SHBG correlated with worse severity only in women; testosterone, estradiol, DHEAS and vitamin D showed no association.
- Assessment of Occipital Involvement Among a Large Population of Females with Pattern Hair Loss in Saudi Arabia In 1,000 women with female pattern hair loss, one-third had occipital involvement, limiting donor supply for hair transplantation.
- Study of Drug Target Identification and Associated Molecular Mechanisms for the Therapeutic Activity and Hair Follicle Induction of Two Ashwagandha Extracts Having Differential Withanolide Constitutions In dermal papilla cells, an ashwagandha extract's effects on beta-catenin and TERT depended on its withanolide composition, arguing for standardised extracts.
- Clinicopathological characteristics of fibrosing alopecia in a pattern distribution: a single‐center, retrospective study In 20 fibrosing alopecia in a pattern distribution patients, characteristic trichoscopic and histologic features were defined, with younger patients at higher risk than thought.
- Melatonin protects K15+ human hair follicle stem cells and hair matrix keratinocytes against paclitaxel-induced damage ex vivo Melatonin protected human hair follicle stem cells and matrix keratinocytes against paclitaxel damage ex vivo.
- Evaluating subjective versus objective measures of changes in hair density using standardized scalp photography Subjective versus objective measures of hair density change were evaluated using standardized scalp photography.
- The Rho GTPase exchange factor Vav2 promotes extensive age-dependent rewiring of the hair follicle stem cell transcriptome In mice, active Vav2 rewires skin stem-cell gene expression in age-dependent waves, altering stem-cell functional states.
- Non-invasive assessment of hair regeneration in androgenetic alopecia mice in vivo using two-photon and second harmonic generation imaging Two-photon and harmonic imaging non-invasively tracked delayed regrowth and follicle miniaturization in androgenetic alopecia mice.
- Efficacy of Baricitinib in Patients with Various Degrees of Alopecia Areata Severity: Post-Hoc Analysis from BRAVE AA1 and BRAVE AA2 Pooled phase 3 data showed baricitinib 4 mg gave faster, higher regrowth than 2 mg, with slower response in SALT 95-100 patients.
- Treatments for Dissecting Cellulitis of the Scalp: A Systematic Review and Treatment Algorithm A systematic review of 417 dissecting cellulitis patients found most evidence is case reports; oral retinoids and photodynamic therapy are best studied.
- Identification of immune microenvironment changes, immune-related pathways and genes in male androgenetic alopecia Gene-expression reanalysis found increased immune cell infiltration and four hub immune genes in balding male scalps.
- Clinical effects of autologous follicular unit extraction transplantation in the treatment of secondary cicatricial alopecia after infections Nine patients with infection-related scarring alopecia had 89% satisfaction 12 months after follicular unit extraction transplantation.
- Loss of Dicer in Newborn Melanocytes Leads to Premature Hair Graying and Changes in Integrin Expression In mice and cell lines, loss of Dicer in melanocytes depletes melanocyte stem cells via the miR-92b–ItgaV pathway, linking stress to premature hair graying.
- Efficacy and safety of baricitinib in patients with alopecia areata: evidence to date A review summarizes baricitinib's mechanism and evidence base as an approved JAK1/2 inhibitor treatment for alopecia areata.
- Treatment Patterns for Alopecia Areata in the US In 45,000 US adults with alopecia areata, corticosteroids dominated treatment and over two-thirds were off all treatment by 12 months.
- Effectiveness of Tofacitinib in Pre-adolescent Alopecia Areata: A Retrospective Case Series and Literature Review A retrospective series found oral tofacitinib produced hair regrowth in 9 of 11 pre-adolescent alopecia areata patients with only mild adverse events.
- Botulinum Toxin A for Hair Loss Treatment: A Systematic Review of Efficacy, Safety, and Future Directions A systematic review maps mechanisms, safety and research gaps for botulinum toxin A in hair loss without reporting a pooled efficacy result.
- Follicle-Targeted Delivery of Betamethasone and Minoxidil Co-Entrapped in Polymeric and Lipid Nanoparticles for Topical Alopecia Areata Treatment In lab skin models, lipid nanoparticles boosted follicular delivery of minoxidil tenfold and betamethasone more than polymeric nanoparticles or controls.
- Hair disorders associated with post-COVID-19 infection in females: a cross-sectional study A survey found 61% of women reported hair problems after COVID-19, mostly telogen effluvium confirmed by trichoscopy.
- Hair Loss Profiles and Ritlecitinib Efficacy in Patients with Alopecia Areata: Post Hoc Analysis of the ALLEGRO Phase 2b/3 Study Post hoc analysis of the ALLEGRO trial identified five hair-loss profiles in alopecia areata, and ritlecitinib outperformed placebo regardless of profile.
- Female diffuse non‐cicatricial alopecia—The diagnostic value of trichoscopy A report lists clinical and trichoscopy findings in female diffuse non-scarring alopecia to show trichoscopy can often replace biopsy.
- Topical cetirizine for the management of androgenic alopecia: Results of a pilot study A pilot study tested topical cetirizine for androgenetic alopecia.
- Clinical effectiveness of finasteride versus hydroxychloroquine in the treatment of frontal fibrosing alopecia: A randomized controlled trial In 34 women with frontal fibrosing alopecia, low-dose finasteride and hydroxychloroquine were equally effective and well tolerated over six months.
- Associations between season, climate, and pediatric alopecia areata flares in Providence, Rhode Island A chart review of 123 children found alopecia areata flares peaked in winter and correlated with air pressure and sunlight.
- Quantification of Squalene and Lactic Acid in Hair Bulbs with Damaged Sheaths: Are They Metabolic Wastes in Alopecia? Chemical analysis of hair bulbs found elevated squalene only in alopecia patients with damaged hair sheaths, suggesting a pathogenic marker.
- Increased prescriptions of oral minoxidil after a high-profile newspaper article about its benefits for hair loss Oral minoxidil prescriptions rose after a high-profile newspaper article promoted its benefits for hair loss.
- Inverse correlation between vitamin D and CRP levels in alopecia areata: A pilot study A pilot study found low vitamin D correlated with higher CRP in alopecia areata, with deficiency more common in the universalis form.
- Adipose transcriptome in the scalp of androgenetic alopecia RNA sequencing of four men's scalps showed downregulated PPARγ adipogenesis signaling in bald versus occipital scalp fat.
- VDR is an essential regulator of hair follicle regression through the progression of cell death In Vdr-knockout mice, the hair cycle stalls in catagen because epithelial strands fail to regress, identifying VDR as a regulator of follicle regression.
- Scalp bacterial species influence <i>SIRT1</i> and <i>TERT</i> expression in keratinocytes In cultured keratinocytes, common scalp bacteria raised or lowered SIRT1 and TERT gene expression, suggesting scalp microbes influence hair growth.
- Could red and near-infrared emitting fabric technology improve the severity of psoriasis, polymorphous light eruption, and alopecia areata? In a 14-patient pilot, three alopecia areata patients wearing red/near-infrared-emitting garments all improved their SALT scores over 12 weeks.
- Effect of two shampoo formulations on the prokaryotic and eukaryotic microbiota composition of the human scalp In 50 volunteers, two non-antimicrobial shampoos used 2 weeks increased fungal counts but did not alter overall scalp microbial community composition.
- mTOR signaling in hair follicle and hair diseases: recent progress A review describes how mTOR signaling maintains hair follicle stem cells and may link vitamin D receptor deficiency to alopecia.
- Refractory Folliculitis Decalvans Treatment Success with a Novel Surgical Excision Approach Using Guarded High-Tension Sutures Surgical excision with guarded high-tension sutures healed refractory folliculitis decalvans lesions in five patients with no recurrence at 10–24 months.
- Hair loss treatments take aim at the immune system Hair loss treatments under development are taking aim at the immune system.
- Anxiety and Depression in Patients with Alopecia Areata in Eskisehir, Turkey Turkish patients with alopecia areata had significantly more depression (30%) and anxiety (20%) than healthy controls.
- Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles A Taiwanese genome-wide study identified seven SNPs and four HLA genotypes associated with alopecia areata susceptibility.
- Four fixed points for dermoscope in male androgenetic alopecia: A way to diagnosis and monitor therapy effect A letter proposes imaging four fixed scalp points with dermoscopy to diagnose androgenetic alopecia and monitor treatment response.
- Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome In Chinese women with sensitive scalp, a Saccharomyces-Lactobacillus ferment applied 28 days shifted scalp microbes and self-reported symptom relief was 100%.
- Alopecia Areata: The Clinician and Patient Voice A review of clinician and patient surveys discusses unmet needs and gaps in alopecia areata care.
- The Association between Number of Follicular Stelae and Severity and Treatment Response of Alopecia Areata Cases: A Retrospective Study In 142 alopecia areata biopsies, follicular stelae counts correlated with disease severity but not with treatment response.
- Low Molecular Weight Collagen Peptide (LMWCP) Promotes Hair Growth by Activating the Wnt/GSK-3β/β-Catenin Signaling Pathway
- Complementary and alternative supplements: a review of dermatologic effectiveness for androgenetic alopecia
- Hair-to-Hair Trichoscopy: An Objective Method to Assess Effectiveness of Botulinum Toxin in a Clinical Trial for Androgenetic Alopecia