May 202349
Combination therapy for female pattern hair loss was concluded to outperform any single drug, and PRP-fibroblast growth factor with minoxidil improved growth more than either alone. Oral minoxidil, topical finasteride, PRP and laser were reported effective options, though evidence quality varies. A therapy update covered mechanisms, costs and efficacy of approved and emerging options. PRP plus redensyl, saw palmetto and biotin outperformed PRP with Procapil. Dental pulp stem cell conditioned media improved androgenetic alopecia in most treated men. 675 nm laser therapy increased shaft density and reduced miniaturization. Baricitinib for alopecia areata beat placebo in phase 3 trials, with long-term safety data still needed.
- Combination therapy in female pattern hair loss A review concludes combining treatments such as minoxidil, spironolactone and finasteride outperforms any single drug for female pattern hair loss.
- Evaluation of platelet‐rich plasma plus basic fibroblast growth factor combined with minoxidil in the treatment of androgenetic alopecia: A randomized controlled trial In a 75-patient randomized trial, combining PRP-fibroblast growth factor injections with minoxidil improved hair growth more than either treatment alone.
- Androgenetic Alopecia: Therapy Update A review covers mechanisms, costs, efficacy and safety of approved and emerging androgenetic alopecia treatments.
- Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs A review finds oral minoxidil, topical finasteride, PRP and laser therapy promising for AGA but notes evidence quality varies and trials are needed.
- Experience of Novelty Laser Therapy Emission with 675 nm Wavelength for the Treatment of Androgenetic Alopecia in Male and Female Patients: A Case Series Study In a 17-patient case series, ten sessions of 675 nm laser increased hair shaft density and reduced miniaturization by 60% without side effects.
- Repurposing DPP4-Inhibition to Improve Hair Follicle Activation and Regeneration In mouse models, topical DPP4 inhibitor sitagliptin accelerated anagen and regenerated follicles in wounds via Wnt/Lef1.
- mTORC1 activity negatively regulates human hair follicle growth and pigmentation In organ-cultured human hair follicles, inhibiting mTORC1 with rapamycin stimulated hair growth and pigmentation, even in gray follicles.
- MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells In mice, inducing miR-205 softened hair follicle stem cell mechanics and activated hair regeneration in young and old animals.
- Baricitinib for the Treatment of Alopecia Areata A review: baricitinib beat placebo in phase 3 trials and is now EMA- and FDA-approved for severe alopecia areata; long-term safety data still needed.
- Surgical Management for Hair Restoration: A Review of Contemporary Techniques A review of contemporary surgical hair restoration: flaps, scalp reduction and FUE/FUT transplantation, chosen by etiology and patient factors.
- DKK1-targeting cholesterol-modified siRNA implication in hair growth regulation In mice, a DKK1-targeting siRNA promoted hair growth comparable to 5% minoxidil via Wnt/β-catenin activation.
- Noninvasive Hair Rejuvenation A review of nonsurgical hair restoration: minoxidil, finasteride, laser therapy and PRP for androgenetic alopecia.
- Millet seed oil activates β–catenin signaling and promotes hair growth In testosterone-treated mice, oral millet seed oil promoted hair growth via β-catenin signaling.
- Trichoscopic evaluation of dental pulp stem cell conditioned media for androgenic alopecia. In 33 men, dental pulp stem cell conditioned media improved androgenetic alopecia in 75% of subjects with only mild transient side effects.
- A Comparative Study of Topical Procapil With Platelet-Rich Plasma Therapy Versus Topical Redensyl, Saw Palmetto, and Biotin With Platelet-Rich Plasma Therapy in the Treatment of Androgenetic Alopecia. In a 54-man trial, PRP plus redensyl, saw palmetto and biotin outperformed PRP plus Procapil for androgenetic alopecia.
- Prospective Efficacy and Safety Study of an Innovative Kerascalp Hair Growth Serum in Mild-to-Moderate Alopecia in India: Regrowth Study A 30-person open-label study of a botanical hair serum reported improved density, thickness and reduced shedding over 90 days.
- Recent Advances in Understanding of the Etiopathogenesis, Diagnosis, and Management of Hair Loss Diseases A review updating etiopathogenesis, diagnosis and management of AGA, female pattern hair loss, alopecia areata and cicatricial alopecias.
- Circulating and/or cutaneous irisin resistance: A novel link among androgenetic alopecia, comorbid metabolic syndrome and cardiovascular risks In a case-control study, pattern hair loss patients showed elevated irisin linked to metabolic syndrome and thickened carotid arteries.
- Safety of Janus Kinase inhibitors in Patients with Alopecia Areata: A Systematic Review duplicate
- Real-World, Open-Label Study of the Efficacy and Safety of a Novel Serum in Androgenetic Alopecia In an uncontrolled 150-person study, a twice-daily botanical serum improved hair growth and reduced shedding after 8 weeks.
- Bilayer Silk Fibroin/Sodium Alginate Scaffold Delivered hUC-MSCs to Enhance Skin Scarless Healing and Hair Follicle Regeneration with the IRE1/XBP1 Pathway Inhibition A silk fibroin/alginate scaffold delivering stem cells enhanced scarless healing and follicle regeneration in wound models.
- iPSC-based approach for human hair follicle regeneration A review of iPSC-based strategies for bioengineering human hair follicles, still not clinically achievable.
- Recent Trends in Macromolecule‐Based Approaches for Hair Loss Treatment A review of macromolecule, microneedle and nanoparticle approaches for hair regeneration, still preclinical.
- Plasma Rich in Growth Factors as an Adjuvant Treatment for the Management of Frontal Fibrosing Alopecia: A Retrospective Observational Clinical Study In a retrospective study of 118 frontal fibrosing alopecia patients, adding PRGF to conventional treatment improved regrowth and severity scores.
- Male pattern hair loss: Can developmental origins explain the pattern? A viewpoint article proposing that developmental origins of scalp skin explain why pattern hair loss spares the back of the head.
- Medicinal and edible plant Allium macrostemon Bunge for the treatment of testosterone-induced androgenetic alopecia in mice In mice, Allium macrostemon extract regrew hair by activating Wnt/β-catenin signaling in dermal papilla cells.
- SIRT1 downregulation provokes immune-inflammatory responses in hair follicle outer root sheath cells and may contribute to development of alopecia areata In hair follicle cells and mice, reduced SIRT1 triggered immune-inflammatory signals that may drive alopecia areata development.
- Factors predicting response to oral methylprednisolone tapering treatment in alopecia areata: A retrospective study a retrospective study examining which factors predict response to oral methylprednisolone tapering in alopecia areata.
- Construction of regulatory network for alopecia areata progression and identification of immune monitoring genes based on multiple machine-learning algorithms A machine-learning analysis identified four genes, including LGR5, as potential markers for predicting severe alopecia areata.
- The modified HoVert ( mHoVert ) method improves diagnostic certainty compared to the St John's protocol for alopecia biopsy specimens: A retrospective single center study The mHoVert biopsy method gave more certain alopecia diagnoses (66% vs 46%) than the St John's protocol, without DIF.
- Mechanisms of impairment in hair and scalp induced by hair dyeing and perming and potential interventions A review of how dyeing and perming damage the hair shaft and scalp and possible interventions.
- Drug-induced alopecia areata: A systematic review a systematic review cataloguing drugs reported to trigger alopecia areata.
- Clinical factors and hair care practices influencing outcomes in central centrifugal cicatricial alopecia In 100 CCCA patients, natural hairstyles, hooded dryer use and no thyroid disease predicted improvement after one year of treatment.
- The medicinal activity of lyophilized aqueous seed extract of Lepidium sativum L. in an androgenic alopecia model In rats, topical Lepidium sativum seed extract improved hair length similarly to minoxidil and lowered androgenic markers.
- EGFR marks a subpopulation of dermal mesenchymal cells highly expressing IGF1 which enhances hair follicle regeneration. In mice, EGFR-positive dermal fibroblasts secrete IGF1 that promotes wound-induced hair follicle neogenesis.
- Changes in Minoxidil Prescribing After Media Attention About Oral Use for Hair Loss a study of how media coverage changed minoxidil prescribing for hair loss.
- Case series evaluating the efficacy and safety of platelet-rich plasma for androgenetic alopecia in pediatric patients. a case series evaluating PRP efficacy and safety for androgenetic alopecia in children.
- Multivariate analysis of clinical characteristics and prognostic factors in early-onset alopecia areata: a retrospective study with 82 Brazilian patients a retrospective study of 82 Brazilian patients examining clinical features and prognostic factors in early-onset alopecia areata.
- Selective Delivery of Tofacitinib Citrate to Hair Follicles Using Lipid-Coated Calcium Carbonate Nanocarrier Controls Chemotherapy-Induced Alopecia Areata In mice, lipid-coated nanoparticles delivering tofacitinib to follicles reduced chemotherapy-induced hair loss better than topical tofacitinib solution.
- Effects of Allium hookeri Extracts on Hair-Inductive and Anti-Oxidative Properties in Human Dermal Papilla Cells In cultured human dermal papilla cells, Allium hookeri extract boosted growth-related genes and antioxidant defenses.
- Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes In cell experiments, silencing the ABCA4 gene worsens damage from toxic vitamin A derivatives in human hair follicle stem cells.
- Skin cancer in patients treated with photobiomodulation for alopecia: a retrospective chart review a retrospective chart review of skin cancer in patients treated with photobiomodulation for alopecia.
- The potential of regulatory T cell-based therapies for alopecia areata A review discusses boosting regulatory T cells, via CAR-Tregs or low-dose IL-2, as a future alopecia areata strategy.
- Proteomic Identification and Quantification of Secretory Proteins in Human Dermal Fibroblast-Conditioned Medium for Wound Repair and Hair Regeneration Lab analysis identified 337 proteins in fibroblast-conditioned medium, 57 linked to hair regeneration.
- Considering the risk of a coloring shampoo with the function of gray hair cover cosmetology and skin barrier: A systematic review A systematic review finds coloring shampoos containing trihydroxybenzene can damage the scalp skin barrier, and frequent use may have various harmful scalp effects.
- Alopecia Areata: An Updated Review for 2023 a 2023 updated review of alopecia areata covering current understanding and treatments.
- Alopecia and Periodontitis: Exploring the connecting dots A review proposing a link between alopecia areata and periodontitis via stress and autoimmunity.
- Deciphering gynaecological pathologies in women with acne and alopecia: an imaging experience. In 115 women with acne and/or androgenic alopecia, over half had polycystic ovarian morphology on ultrasound.
- Evaluation of hair regrowth after minoxidil and dutasteride tattooing in men with androgenetic alopecia