February 202331
PRP injections in men with moderate AGA matched 5% minoxidil in a randomized trial but brought more adverse events and lower satisfaction. Non-adherent topical minoxidil users usually quit within three months citing no improvement, a survey found, suggesting education past that mark helps. A review found topical melatonin improved scalp hair growth and density, particularly in men with AGA. Another review found natural compounds for hair loss, including saw palmetto, nettle and pumpkin seed, improved hair loss mainly through anti-inflammatory and antioxidant effects. In severe alopecia areata, baricitinib over 52 weeks showed response rates improving through the year, with no new safety signals reported.
- Efficacy of autologous Platelet-rich plasma therapy versus topical Minoxidil in men with moderate androgenetic alopecia: A randomized open-label trial In a randomized trial, PRP injections matched 5% minoxidil for moderate male AGA but caused more adverse events and lower patient satisfaction.
- Topical Minoxidil Adherence in Patients With Alopecia In a 99-patient survey, non-adherent topical minoxidil users usually quit within 3 months citing no improvement; education past the 3-month mark may improve adherence.
- Melatonin and the Human Hair Follicle A review of 11 human studies found topical melatonin (0.0033% or 0.1% once daily for 90–180 days) improved scalp hair growth and density, particularly in men with AGA.
- Efficacy and Safety of Baricitinib in Patients with Severe Alopecia Areata over 52 Weeks of Continuous Therapy in Two Phase III Trials (BRAVE-AA1 and BRAVE-AA2) In two phase 3 trials of severe alopecia areata, baricitinib response rates improved through 52 weeks (up to 41% reaching ≤20% scalp loss) with no new safety signals.
- Reducing Surgical Risks for Hair Replacement Surgery This review discusses surgical risks of hair replacement surgery and methods to prevent them.
- Duo-role Platelet-rich Plasma: temperature-induced fibrin gel and growth factors’ reservoir for microneedles to promote hair regrowth A painless, storable PRP microneedle patch released growth factors for days and promoted hair regrowth in mice via angiogenesis and proliferation.
- A Comprehensive Review of Microneedling as a Potential Treatment Option for Androgenetic Alopecia A review examines microneedling as a potential treatment option for androgenetic alopecia.
- Hair loss during and after breast cancer therapy This review covers mechanisms, prevention, and treatment of hair loss from breast cancer surgery, chemotherapy, and endocrine therapy.
- Scalp hair loss is not random across follicular units: A new insight into human hair ageing In 400 Chinese adults, age-related scalp hair loss preferentially hit multi-hair follicular units, especially in men, rather than occurring randomly.
- CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2 CXXC5 mediates DHT- and PGD2-induced hair loss by suppressing Wnt/β-catenin signaling; blocking it restored hair growth in lab models.
- Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth ISX9, a small molecule that activates Wnt/β-catenin signalling by binding Axin1, promoted hair regrowth and follicle activation in mice.
- Natural Compounds Used for Treating Hair Loss A review finds plants like saw palmetto, nettle and pumpkin seed, plus micronutrients and keratin, show promise for hair loss, mostly via anti-inflammatory and antioxidant effects.
- Caizhixuan hair tonic regulates both apoptosis and the PI3K/Akt pathway to treat androgenetic alopecia Caizhixuan hair tonic promoted hair growth in androgenetic alopecia mice by regulating PI3K/Akt and apoptosis pathways.
- Prognosis in patients with alopecia areata with poliosis: A retrospective cohort study of 479 cases prognosis in patients with alopecia areata with poliosis, a retrospective cohort study of 479 cases.
- Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata ILC1-like innate lymphocytes alone sufficed to induce alopecia areata lesions in human hair follicles ex vivo and in mice, questioning whether AA always requires CD8+ T cells.
- Fractional carbon dioxide laser alone and as an assisted drug delivery for treatment of alopecia areata: a clinical, dermoscopic and immunohistochemical study In 64 alopecia areata patients, fractional CO2 laser alone or with triamcinolone, PRP or vitamin D3 all significantly improved severity scores similarly.
- Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice In mice, injury-induced IL-1α promoted de novo hair follicle regeneration and Lgr5 stem cell proliferation.
- Water extract of cacumen platycladi promotes hair growth through the Akt/GSK3β/β-catenin signaling pathway Water extract of Platycladus orientalis needles promoted hair growth in mice via the Akt/GSK3β/β-catenin pathway, comparable to finasteride at high dose.
- Laser and light therapy combined with topical minoxidil for alopecia areata: a systematic review and meta-analysis of randomized controlled trials A meta-analysis of 10 RCTs found lasers/light plus topical minoxidil improved alopecia areata response and reduced recurrence versus minoxidil alone, with low-quality evidence.
- Effects of Cudrania tricuspidata and Sargassum fusiforme extracts on hair growth in C57BL/6 mice In mice, Cudrania tricuspidata and Sargassum fusiforme extracts increased hair growth by upregulating anagen genes.
- Perifollicular Microscarring in Alopecia Areata and Pattern Hair Loss perifollicular microscarring in alopecia areata and pattern hair loss.
- Dermal PapillaCell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1 Dermal papilla cell-derived exosomes stimulated hair follicle stem cell proliferation via LEF1 in cell culture.
- Treatment of alopecia areata with the janus kinase inhibitor upadacitinib: A retrospective cohort study A retrospective cohort examined upadacitinib treatment for alopecia areata.
- Exploration of integrated targeted serum and hair metabolomic profiles in men with androgenetic alopecia Serum and hair metabolomic profiles were explored in men with androgenetic alopecia.
- Expansion Culture of Hair Follicle Stem Cells through Uniform Aggregation in Microwell Array Devices Microwell culture expanded hair follicle stem cells 20-fold and regenerated hair in nude mice, and improved marker expression in human cells.
- Combined microneedling with topical vitamin D3 or bimatoprost versus microneedling alone in the treatment of alopecia areata: A comparative randomized trial In 75 alopecia areata patients, microneedling combined with topical vitamin D3 or bimatoprost gave higher regrowth than microneedling alone, with mild transient side effects.
- Alopecia areata in underrepresented groups: preliminary analysis of the all of us research program In the All of Us cohort (0.30% AA prevalence), Black and Hispanic participants had roughly twice the odds of AA; lower prevalence in low-income groups may reflect underdiagnosis.
- Patterns of insurance coverage for wigs in patients with alopecia areata: a cross-sectional survey Survey of 626 alopecia areata patients: wigs averaged $1,543, only 23% of those seeking insurance coverage received it, and most found coverage inadequate.
- Examining the Effect of Notocactus ottonis Cold Vacuum Isolated Plant Cell Extract on Hair Growth in C57BL/6 Mice Using a Combination of Physiological and OMICS Analyses In mice, a cactus cell extract promoted hair growth comparably to minoxidil and increased follicle numbers.
- Hair regrowth boosting via minoxidil cubosomes: Formulation development, in vivo hair regrowth evaluation, histopathological examination and confocal laser microscopy imaging Minoxidil-loaded cubosome nanoparticles penetrated skin better and boosted hair regrowth more than standard minoxidil solution in animals, with good tolerability.
- Mesotherapy with dutasteride for androgenetic alopecia: a concise review of the literature A concise review covers dutasteride mesotherapy injections for androgenetic alopecia.