October 202457
Oral versus topical minoxidil was found equally effective, though oral doubled hypertrichosis risk while hypotension rates did not differ. Topical ethinylestradiol added to minoxidil showed no benefit over minoxidil alone and caused more menstrual irregularities. Low-level laser and LED therapy increased hair density versus placebo. Micronutrient deficiencies were linked to pattern hair loss as modifiable risk factors, though evidence remains inconsistent. Exosome treatments for hair loss have reached only 125 patients with rare side effects, though serious adverse events occurred in wider dermatology use. Perioperative hair transplant practices produced 41 best practices across seven categories. Autologous micrografts with exosomes raised density about 28-30 hairs/cm² at twelve months. Red and green LED therapy both improved density and thickness, with red slightly superior on some measures.
- Exosomes for Treating Hair Loss: A Review of Clinical Studies A review found only 125 patients have received exosome hair-loss treatments, with rare side effects, but evidence is limited and serious adverse events have occurred in wider dermatology use.
- Micronutrients and Androgenetic Alopecia: A Systematic Review A systematic review linked vitamin B, vitamin D, iron, selenium, and zinc deficiencies to AGA as modifiable risk factors, though evidence remains inconsistent.
- Efficacy and safety of oral minoxidil versus topical solution in androgenetic alopecia: a meta‐analysis of randomized clinical trials A meta-analysis of four trials found oral and topical minoxidil equally effective for AGA, but oral doubled hypertrichosis risk; hypotension rates did not differ significantly.
- Efficacy and safety of combined topical ethinylestradiol with minoxidil versus topical minoxidil in female pattern hair loss. A trichoscopic randomized controlled clinical study In 43 women with female pattern hair loss, adding topical ethinylestradiol to minoxidil gave no significant benefit over minoxidil alone and caused more menstrual irregularities.
- Low-Level Laser and LED Therapy in Alopecia: A Systematic Review and Meta-Analysis A meta-analysis of 38 studies found low-level laser/LED therapy significantly increased hair density versus placebo in androgenetic alopecia.
- Tolerance and Safety Profile of Sublingual Minoxidil in the Treatment of Androgenic Alopecia examines the tolerance and safety profile of sublingual minoxidil for androgenic alopecia.
- Summary of Best Evidence for Perioperative Management Practices in Hair Transplantation Patients A review of 22 high-quality guidelines and consensuses summarizes 41 best practices for perioperative hair transplant care across seven categories.
- Autologous Micrografts Containing Nanovesicles, Exosomes, and Follicle Stem Cells in Androgenetic Alopecia: In Vitro and In Vivo Analysis Through a Multicentric, Observational, Evaluator-Blinded Study In an uncontrolled 60-patient study, autologous micrografts with follicle stem cells and exosomes raised hair density about 28-30 hairs/cm² at 12 months.
- A phase 2a trial of brepocitinib for cicatricial alopecia In a phase 2a trial, brepocitinib reduced inflammatory biomarkers and improved clinical severity in cicatricial (scarring) alopecia, with good tolerability.
- Systematic review and indirect treatment comparisons of ritlecitinib against baricitinib in alopecia areata Indirect comparisons of four trials found similar efficacy between ritlecitinib 50 mg and baricitinib 4 mg in severe alopecia areata, with considerable uncertainty.
- Patient-Reported Hair Loss and Its Impacts as Measured by the Alopecia Areata Patient Priority Outcomes Instrument in Patients Treated with Ritlecitinib: The ALLEGRO Phase 2b/3 Randomized Clinical Trial In the ALLEGRO phase 2b/3 trial, patient-reported hair improvement on ritlecitinib tracked clinician-measured regrowth, though emotional and activity scores changed little.
- A Comprehensive Review of Microneedling as a Potential Treatment Option for Androgenetic Alopecia a comprehensive review assessing microneedling as a potential treatment option for androgenetic alopecia.
- AIMP1-Derived Peptide Secreted from Hair Follicle Stem Cells Promotes Hair Growth by Activating Dermal Papilla Cells An AIMP1-derived peptide secreted by hair follicle stem cells activated dermal papilla cells and sped hair regrowth in mice.
- Platinum Nanozyme‐Loaded Dissolving Microneedles Scavenge ROS and Promote Lineage Progression for Androgenetic Alopecia Treatment In mice, platinum nanozyme-loaded dissolving microneedles cleared oxidative stress and regrew hair faster than daily minoxidil, with no organ platinum retention.
- Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata An integrated analysis of the ALLEGRO trials found ritlecitinib's hair regrowth in alopecia areata increased through month 24, with a safety profile consistent with prior data.
- British Association of Dermatologists living guideline for managing people with alopecia areata 2024 The British Association of Dermatologists' 2024 guideline issues 49 recommendations for managing alopecia areata across all ages.
- Sustained hair regrowth with continued ritlecitinib treatment through week 48 in patients with alopecia areata with or without early target responses: Post hoc analysis of the ALLEGRO phase 2b/3 trial A post hoc ALLEGRO analysis found week-24 ritlecitinib responses mostly held to week 48, and up to a third of early nonresponders responded with continued treatment.
- Long‐term outcomes of intravenous corticosteroid pulse therapy for rapidly progressive alopecia areata: A single‐center retrospective analysis of 106 cases and usefulness evaluation of a scoring system originally designed for half‐year efficacy prediction for extended periods In 106 rapidly progressive alopecia areata patients, intravenous corticosteroid pulse therapy plus follow-up treatments achieved good long-term response in 74.5%.
- Scalp dose analysis for transient and permanent alopecia following conventional cranial irradiation using Image Guided Radiotherapy (IGRT): A prospective study In 48 brain-tumor radiotherapy patients, scalp dose predicted hair loss, with thresholds of 22.15 Gy for transient and 36.81 Gy for permanent alopecia.
- Piperonylic Acid Promotes Hair Growth by Activation of EGFR and Wnt/β-Catenin Pathway Piperonylic acid activated EGFR and Wnt/β-catenin in dermal papilla cells, and a formulation containing it increased hair counts versus placebo in a clinical study.
- Red and Green LED Light Therapy: A Comparative Study in Androgenetic Alopecia In 17 AGA patients, both red and green LED therapy improved hair density and thickness over six months, with red slightly superior on some measures.
- Evaluation of the relationship between serum G protein-coupled estrogen receptors (GPER-1) levels and the severity and duration of the disease in patients with androgenetic alopecia: A case-control study Serum GPER-1 estrogen receptor levels were higher in AGA patients than controls and correlated with disease severity and duration.
- Atraric Acid Induces Hair Growth through the Stimulation of Sonic Hedgehog/GLI1 in Human Dermal Papilla Cells Atraric acid induces hair growth by stimulating Sonic Hedgehog/GLI1 signaling in human dermal papilla cells.
- The Proportion of Catagen and Telogen Hair Follicles in Occipital Scalp of Male Androgenetic Alopecia Patients: Challenging the Established Dogma Examination of follicles from 14 men's occipital scalps found more catagen (7.5%) than telogen (3.5%) follicles, challenging standard hair-cycle figures.
- Dupilumab and Alopecia Areata: A Possible Combined or Disturbance Therapy? A Review of the Literature A review of 51 cases found dupilumab worsened alopecia areata in 13 patients but improved it in 38, possibly depending on Th1 versus Th2 immune profiles.
- Concordance Among In-Vivo Reflectance Confocal Microscopy, Trichoscopy, and Histopathology in the Evaluation of Alopecia Areata Incognita Reflectance confocal microscopy agreed substantially with histopathology in diagnosing alopecia areata incognita in 12 women.
- The empowering influence of air-liquid interface culture on skin organoid hair follicle development Air-liquid interface culture produced more and larger hair follicles in lab-grown skin organoids than conventional floating culture.
- Postpartum hair loss is associated with anxiety Among 331 postpartum women, severe hair loss was independently associated with four-fold higher odds of anxiety.
- Investigating the role of keratin proteins and microbial associations in hereditary and pathogenic alopecia A computational analysis identified an LPAR6 mutation linked to hereditary hair loss and keratin protein structures associated with alopecia.
- Effectiveness of Generic Tofacitinib in the Treatment of Patients with Mild Alopecia Areata in China: A Retrospective Real-World Study a retrospective real-world study of generic tofacitinib for mild alopecia areata in China.
- Assessment of the Role of miR‐30a‐5p on the Proliferation and Apoptosis of Hair Follicle Stem Cells In rat hair follicle stem cells, reducing miR-30a-5p promoted proliferation and inhibited apoptosis via Wnt/β-catenin signaling.
- Oral abrocitinib for treatment of refractory alopecia areata: A retrospective study a retrospective study of oral abrocitinib for refractory alopecia areata.
- Nutritional and Microbial Strategies for Treating Acne, Alopecia, and Atopic Dermatitis A review suggests plant-based diets and probiotics may improve acne, alopecia and atopic dermatitis via the gut microbiome, though more research is needed.
- Materials-based hair follicle engineering: Basic components and recent advances A review summarizes recent advances in biomaterials-based hair follicle engineering for regeneration and drug screening.
- Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing A humanized anti-CXCL12 antibody delayed alopecia areata onset in mice by dampening CD8+ T-cell activation.
- The role of salivary vitamin D and interleukin-6 on non-scarring Alopecia In 51 patients with non-scarring alopecia, salivary vitamin D was lower and IL-6 higher than in 50 healthy controls.
- Alopecia Areata Treatment Patterns and Satisfaction: Results of a Real-World Cross-Sectional Survey in Europe A five-country survey of 1720 alopecia areata patients found dermatologists satisfied with traditional therapies in under 30% of those with extensive scalp hair loss.
- Radially patterned morphogenesis of murine hair follicle placodes ensures robust epithelial budding In mice, Wnt and Shh signaling create radial cell patterns that guide hair follicle bud formation during development.
- Alopecia Areata and malignancies: uncertainties clarified by a large-scale population-based study A 51,561-patient population study found alopecia areata associated with hematological malignancies, especially non-Hodgkin lymphoma, but not solid tumors overall.
- Effects of oxytocin receptor agonists on hair growth promotion In dermal papilla cells and hair follicle organoids, oxytocin receptor agonists WAY267464 and LIT001 promoted hair growth-related gene expression and follicle sprouting.
- Association Between Scalp Microbiota Imbalance, Disease Severity, and Systemic Inflammatory Markers in Alopecia Areata Severe alopecia areata showed pro-inflammatory scalp bacteria correlating with disease severity and systemic inflammatory markers in 24 participants.
- Complete Blood Collection-based Systemic Inflammation Biomarkers as a Severity Biomarker in Alopecia Areata: A Cross-sectional Study A cross-sectional study of 302 patients found blood inflammatory markers (NLR, PLR, SII, WLR) were higher in alopecia areata and rose with severity.
- Intranasal sensitization model of alopecia areata using pertussis toxin as adjuvant Intranasal pertussis toxin plus autoantigen triggered alopecia areata-like disease in 36% of mice, suggesting a possible infection route.
- Depression among Alopecia Areata Patients: Prevalence and associated factors in a Tunisian sample Half of 60 Tunisian alopecia areata patients had depression, linked to younger age, eyebrow or nail involvement, and poor treatment response.
- Psychosocial impact of alopecia areata in paediatric and adolescent populations: A systematic review A systematic review of 10 studies found alopecia areata harms self-esteem, body image and quality of life in children and adolescents.
- A unique approach for investigating skin lesions and their relationship with TCM syndrome differentiation in alopecia areata Dermoscopic signs like vascular patterns and exclamation-mark hairs correlated with traditional Chinese medicine syndromes in alopecia areata.
- The penetration efficiency of a dissolved model drug into hair follicles depends on the concentration of added nanoparticles In pig skin, 4% nanoparticle concentration with circular massage enhanced drug penetration into hair follicles; doubling to 8% added nothing.
- A finasteride patch for the treatment of androgenetic alopecia: A study of promoting permeability strategy using synthetic novel O-acylmenthols combined with ion-pair In mice, a transdermal finasteride patch using permeation enhancers matched oral finasteride for hair growth while producing lower peak blood levels.
- Novel natural lipids based NLC containing finasteride improved androgenetic alopecia treatment in rats In rats, a topical nanostructured lipid carrier finasteride formulation restored hair follicles without detectable systemic absorption.
- Innovative strategies for the discovery of new drugs against alopecia areata: taking aim at the immune system A review outlines alopecia areata mechanisms, current and emerging therapies, and argues new drug discovery strategies remain needed.
- Transcription factor KROX20 marks epithelial stem cell ancestors for hair follicle formation A study identifies KROX20 as a marker of skin stem cells that give rise to hair follicle bulge stem cells and are essential for follicle formation.
- Assessment of Intestinal Free Fatty Acid Binding Protein 4 in Alopecia Areata Patients A 44-patient study found serum FABP4 elevated in alopecia areata and correlated with disease duration, relapses and SALT severity score.
- Efficacy and Tolerability of Brevilin-A, a Natural JAK Inhibitor, in Pediatric Alopecia Areata: A Case Series A case series reports Brevilin-A, a natural topical JAK inhibitor, was safe and effective for pediatric alopecia areata.
- Identification of Potential Hub Genes in Alopecia Areata A bioinformatics analysis identified CD8A and FOXD2-AS1 as potential diagnostic markers and therapeutic targets in alopecia areata.
- Genetic Polymorphisms of Immunity Regulatory Genes and Alopecia Areata Susceptibility in Jordanian Patients A case-control study in 152 Jordanian patients linked CLEC4D gene variants to alopecia areata susceptibility.
- Corrigendum: Stimulation of hair regrowth in an animal model of androgenic alopecia using 2-deoxy-D-ribose
- Synergistic Phytochemical and Pharmacological Actions of Hair RiseTM Microemulsion: A Novel Herbal Formulation for Androgenetic Alopecia and Hair Growth Stimulation