Platelet Lysate Promotes Hair Growth: In Vitro and In Vivo Mechanism and Randomized, Controlled Trial

    March 2023 in “ Biomedicine & pharmacotherapy ”
    Qing Guan, Zehong Guo, Damao Dai … Qian Qu
    Studysummary This study found that platelet lysate significantly improved hair growth and follicle performance in both experimental settings and AGA patients, showing results comparable to platelet-rich plasma.
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    Research cited in this study 30

    1. Hair Regrowth Treatment Efficacy and Resistance in Androgenetic Alopecia: A Systematic Review and Continuous Bayesian Network Meta-Analysis Frontiers in Medicine · 2023
    2. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    3. Platelet Rich Plasma and Its Use in Hair Regrowth: A Review Drug design, development and therapy · 2022
    4. Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia JAMA Dermatology · 2021
    5. Liposomal Honokiol Promotes Hair Growth Via Activating Wnt3a/β-Catenin Signaling Pathway and Downregulating TGF-β1 in C57BL/6N Mice Biomedicine & Pharmacotherapy · 2021
    6. Platelet-Rich Plasma for Androgenic Alopecia: A Randomized, Placebo-Controlled, Double-Blind Study and Combined Mice Model Experiment Journal of Cosmetic Dermatology · 2021
    7. Association of Fibrosis in the Bulge Portion with Hair Follicle Miniaturization in Androgenetic Alopecia Journal of The American Academy of Dermatology · 2021
    8. Platelet Lysate: A Promising Candidate in Regenerative Medicine Regenerative Medicine · 2021
    9. Platelet-Rich Plasma Lacks Evidence of Clinically Significant Improvement in Androgenetic Alopecia Journal of The American Academy of Dermatology · 2020
    10. Autologous Activated Platelet-Rich Plasma in Hair Growth: A Pilot Study in Male Androgenetic Alopecia with In Vitro Bioactivity Investigation Journal of Cosmetic Dermatology · 2020
    11. Platelet Factor 4 Inhibits Human Hair Follicle Growth and Promotes Androgen Receptor Expression in Human Dermal Papilla Cells PeerJ · 2020
    12. Effect of Platelet-Rich Plasma Versus Saline Solution as a Preservation Solution for Hair Transplantation Plastic and reconstructive surgery. Global open · 2020
    13. Pattern Hair Loss: Assessment of Microinflammation in Miniaturized and Terminal Hair Follicles Through Horizontal Histologic Sections Journal of The American Academy of Dermatology · 2020
    14. Platelet-Rich Plasma Associated with Hair Transplants for the Treatment of Androgenetic Alopecia Showed No Benefits Journal of The European Academy of Dermatology and Venereology · 2020
    15. Platelet Sonicates Activate Hair Follicle Stem Cells And Mediate Enhanced Hair Follicle Regeneration Journal of Cellular and Molecular Medicine · 2019
    16. TREM2+ Macrophages Inhibit Hair Growth by Producing Oncostatin M Cell Stem Cell · 2019
    17. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth Cell Stem Cell · 2019
    18. Novel Therapeutic Approaches in Utilizing Platelet Lysate in Regenerative Medicine: Are We Ready for Clinical Use? Journal of cellular physiology · 2019
    19. Treatment of Male Pattern Alopecia with Platelet-Rich Plasma: A Double-Blind Controlled Study with Analysis of Platelet Number and Growth Factor Levels Journal of The American Academy of Dermatology · 2018
    20. A Role for the TGF-β/BMP Co-Receptor Endoglin in the Molecular Oscillator That Regulates the Hair Follicle Cycle Journal of Molecular Cell Biology · 2018
    21. Hair Transplantation Controversies Dermatologic Surgery · 2017
    22. As a Carrier–Transporter for Hair Follicle Reconstitution, Platelet-Rich Plasma Promotes Proliferation and Induction of Mouse Dermal Papilla Cells Scientific Reports · 2017
    23. Human Platelet Lysate Versus Minoxidil Stimulates Hair Growth by Activating Anagen Promoting Signaling Pathways Biomedicine & Pharmacotherapy · 2016
    24. Apoptosis in Follicles of Individuals with Female Pattern Hair Loss Is Associated with Perifollicular Microinflammation International Journal of Cosmetic Science · 2016
    25. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    26. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    27. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    28. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    29. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    30. Human Hair Growth In Vitro Journal of Cell Science · 1990

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    3. Progenic Hair Regrowth Treatment: The Use of Platelet-Released Growth Factors for Treating Androgenetic Alopecia by Activating Hair Follicle Stem Cells Journal of clinical & experimental dermatology research · 2014
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